We Now Know How The Cannabis Plant Produces Its Super-Strength, Pain-Killing Compounds
For the first time, scientists have discovered how the cannabis plant produces molecules that are highly effective at tackling pain. The team behind the research hope their findings might one day help us create new painkillers that come without the troublesome side effect of potential addiction.
The team, based at the University of Guelph, used a combination of genomics and biochemistry to work out how the cannabis plant makes cannflavin A and cannflavin B, two molecules that are 30 times better at quelling inflammation than aspirin.
The molecules are known as flavonoids and we've been aware of their existence since 1985. However, due to strict regulation on cannabis research, work on these molecules has been limited. Now, thanks to Canada’s recent legalization of cannabis, scientists have been able to investigate them unhindered.
The team used biochemical techniques to work out which genes are needed to make the two molecules and which enzymes are involved in the production process. Their findings are published in the journal Phytochemistry.
"Our objective was to better understand how these molecules are made, which is a relatively straightforward exercise these days," said study co-author Professor Tariq Akhtar in a statement. "There are many sequenced genomes that are publicly available, including the genome of Cannabis sativa, which can be mined for information. If you know what you're looking for, one can bring genes to life, so to speak, and piece together how molecules like cannflavins A and B are assembled."
Knowing how cannflavin A and B are made could help us tackle the opioid crisis. The molecules are not psychoactive – they don’t affect the mind, like opioids or the THC in cannabis do – and target pain directly. This means that we could use them to create a new class of painkillers that don’t carry such a risk of addiction. A recent study found that people in Colorado are increasingly using marijuana to treat pain and many have cut down on their opioid use as a result. However, using cannabis in the conventional way does itself carry addiction risks.
"There's clearly a need to develop alternatives for relief of acute and chronic pain that go beyond opioids," said Akhtar. "These molecules are non-psychoactive and they target the inflammation at the source, making them ideal painkillers."
With their new understanding of how these pain-fighting molecules are synthesized, the researchers are now attempting to develop a biological system that can produce them in large quantities. The two flavonoids are produced in small amounts by the cannabis plant, so even genetically engineered plants wouldn’t be able to produce sufficient amounts. The researchers have licensed a patent to produce the two cannflavins outside of the cannabis plant in collaboration with a Canadian company called Anahit International Corp.
"Being able to offer a new pain relief option is exciting, and we are proud that our work has the potential to become a new tool in the pain relief arsenal," said study co-author Professor Steven Rothstein.
https://www.iflscience.com/health-and-m ... compounds/
I have produced & directed a VOYNICH TV SPECIAL: Scientists who have been studying the Voynich manuscript claim that they have been unable to decipher a single word and unable to identify a single plant from this mysterious manuscript. However, in this film, for the first time ever in the history of Voynich research, Chris Everard reveals that some of the illustrations are MICROSCOPIC IMAGES of what are known as TRICHOMES - these are crystals which appear on the leaves of many plants - through a microscope they look like a stalk ending in a spherical ball - and the plant which is most famous for having millions of these TRICHOME CRYSTAL STALKS is CANNABIS….
In fact, not only does the Voynich manuscript contain detailed images of TRICHOME CRYSTALS, but also illustrates the buds of cannabis, the leaves of cannabis and then goes on to explain how the cannabis oils can be diffused and inhaled via tubes and cylinders in relaxing hot steam baths and baths of cannabis-infused clay…
It’s all there - staring at researchers in the face - there’s even illustrated MICROSCOPES just in case the reader can’t understand the drawings… All staring back at us from the pages of an encoded mysterious manuscript written 600 years ago…
Spingola Speaks 2018.8.11
by Deanna Spingola, RBN
Publication date 2018-08-11
Topics Deanna Spingola, RBN
Deanna's guest was Chris Bennett, the author of Liber 420: Cannabis, Magickal Herbs and the Occult
https://www.cannabisculture.com/content ... s-bennett/
Chris Bennett has been researching the historical role of cannabis in the spiritual life of humanity for more than a quarter of a century. He is co-author of Green Gold the Tree of Life: Marijuana in Magic and Religion (1995); Sex, Drugs, Violence and the Bible (2001); and author of Cannabis and the Soma Solution (2010); and Liber 420: Cannabis, Magickal herbs and the Occult (2018). He has also contributed chapters on the historical role of cannabis in spiritual practices in books such as The Pot Book (2010), Entheogens (en-the-o-gen) and the Development of Culture (2013), Seeking the Sacred with Psychoactive Substances (2014), One Toke Closer to God (2017), Cannabis and Spirituality (2016) and Psychedelics Reimagined (1999). Bennett’s research has received international attention from the BBC, Guardian, Sunday Times, Washington Post, Vice and other media sources.
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