Coronavirus Crisis: Main Thread

[drstrangelove]

Ancient History From 2016: "But those nanoparticles can lead to dangerous side effects, especially if a patient has to take repeated doses over months or years."

Very $trange how this widely held view has been conveniently forgotten in our current ru$h to sign kids up for quarterly boo$ter $hot$.

***

Delivery — actually getting RNA into cells — has long bedeviled the whole field. On their own, RNA molecules have a hard time reaching their targets. They work better if they’re wrapped up in a delivery mechanism, such as nanoparticles made of lipids. But those nanoparticles can lead to dangerous side effects, especially if a patient has to take repeated doses over months or years.

Novartis abandoned the related realm of RNA interference over concerns about toxicity, as did Merck and Roche. ...

Moderna’s most advanced competitors, CureVac and BioNTech, have acknowledged the same challenge with mRNA. Each is principally focused on vaccines for infectious disease and cancer, which the companies believe can be attacked with just a few doses of mRNA. And each has already tested its technology on hundreds of patients.

“I would say that mRNA is better suited for diseases where treatment for short duration is sufficiently curative, so the toxicities caused by delivery materials are less likely to occur,” said Katalin Karikó, a pioneer in the field who serves as a vice president at BioNTech.

That makes vaccines the lowest hanging fruit in mRNA, said Franz-Werner Haas, CureVac’s chief corporate officer. “From our point of view, it’s obvious why {Moderna} started there,” he said.

And this:

From the start, Moderna heralded its ability to produce proteins within cells, which could open up a world of therapeutic targets unreachable by conventional drugs. The most revolutionary treatments, which could challenge the multibillion-dollar market for protein therapy, would involve repeated doses of mRNA over many years, so a patient’s body continued to produce proteins to keep disease at bay.

So it is an on going gene therapy that has been marketed as a two shot vaccine with booster shots. It was always known two shots wouldn't be enough.

This whole article is a nugget of information:

“I would say that mRNA is better suited for diseases where treatment for short duration is sufficiently curative, so the toxicities caused by delivery materials are less likely to occur,” said Katalin Karikó, a pioneer in the field who serves as a vice president at BioNTech.

So it is the fucking nanoparticles or lipids that are toxic, as shown in that Japanese toxicity report on rats or mice.

The claims have always been about the mRNA staying in the muscle. Nothing was ever said about the lipid nanoparticles.

I thought those Japanese reports just mapped the spread of the nanoparticles without cell receptors to bind them and transfer the mRNA. Not that they reported any toxicity from them. A lipid is just a fat.

No idea about the specifics. But whatever the thing called a lipid nanoparticle is, it appears to be generally accepted that it was/and or can still be dangerous.

I speed read these and I don't think I'm confusing anything:

"The mRNA-LNP platform’s lipid nanoparticle component used in preclinical vaccine studies is highly inflammatory" - https://www.biorxiv.org/content/10.1101 ... 4.430128v1

"Solid Lipid Nanoparticles for Drug Delivery: Pharmacological and Biopharmaceutical Aspects" - -https://www.frontiersin.org/articles/10.3389/fmolb.2020.587997/full

"Research looks at inflammatory nature of lipid nanoparticle component in mRNA vaccines" - https://www.news-medical.net/news/20210 ... cines.aspx

I generally believe you don't need specialised knowledge to understand things. Those with specialised knowledge(and so nothing else) generally find this view appalling though.

[drstrangelove]

ifr 0.1%

[Harvey]

The claims have always been about the mRNA staying in the muscle. Nothing was ever said about the lipid nanoparticles.

I thought those Japanese reports just mapped the spread of the nanoparticles without cell receptors to bind them and transfer the mRNA. Not that they reported any toxicity from them. A lipid is just a fat.

Your argument is that what is being referred to as 'lipids' by critics and manufacturers, are not synthetic fats created for a specific purpose with regard to these so called vaccines but are exactly the same as those already occurring naturally in the human body?

And you know this because...

[Belligerent Savant]

.

I believe I shared this already; re-posting as it provides a relatively detailed overview of how the vaccines work, presented to physicians.

https://3speak.tv/watch?v=pandemichealt ... ayer_brand


At about 4 minutes into the presentation, the role of the fats/lipids are discussed (along with the antigenic spike proteins):



(At about ~8 min into the presentation he discusses the 'aggregation' of these particles and the potential problems such activity may cause; later he touches on the toxicity of the generated spike proteins, etc)

[Harvey]

^ We'll see if Joe wants to explain his thesis: "...just a fat."

[Belligerent Savant]

.
Yes, the lipids/generated spike proteins are described as synthetic -- the lipids' unique ionizing traits help them bind to other particles/cells (this binding is what can potentially lead to issues -- clotting, etc -- over time)

----------

Related side-note: near-term good news Re: vaccine mandates, at least in the U.S.

https://ohsonline.com/articles/2021/11/ ... s.aspx?m=1

[Belligerent Savant]

.

@jchilders98

The federal judge in our hospital injection mandate case made some very interesting findings about the shots.

Darling et al v. Sacred Heart Health System et al., N.D. Fla. Pensacola Division.

https://twitter.com/jchilders98/status/ ... 90632?s=20

[Harvey]

Austrian junta discussing forced 'vaccination' within a month, support all peoples against this tyranny. I would support them however I can, not just because you and I are next, but because it's the right thing to do.

[Joe Hillshoist]

The claims have always been about the mRNA staying in the muscle. Nothing was ever said about the lipid nanoparticles.

I thought those Japanese reports just mapped the spread of the nanoparticles without cell receptors to bind them and transfer the mRNA. Not that they reported any toxicity from them. A lipid is just a fat.

Your argument is that what is being referred to as 'lipids' by critics and manufacturers, are not synthetic fats created for a specific purpose with regard to these so called vaccines but are exactly the same as those already occurring naturally in the human body?

And you know this because...

No they are different. i just thought that japanese study mapped their movement thru the body (of rats or mice, without mRNA attachments) via the bloodstream. I didn't think it measured damage or anything else.

[Joe Hillshoist]

Ancient History From 2016: "But those nanoparticles can lead to dangerous side effects, especially if a patient has to take repeated doses over months or years."

Very $trange how this widely held view has been conveniently forgotten in our current ru$h to sign kids up for quarterly boo$ter $hot$.

***

Delivery — actually getting RNA into cells — has long bedeviled the whole field. On their own, RNA molecules have a hard time reaching their targets. They work better if they’re wrapped up in a delivery mechanism, such as nanoparticles made of lipids. But those nanoparticles can lead to dangerous side effects, especially if a patient has to take repeated doses over months or years.

Novartis abandoned the related realm of RNA interference over concerns about toxicity, as did Merck and Roche. ...

Moderna’s most advanced competitors, CureVac and BioNTech, have acknowledged the same challenge with mRNA. Each is principally focused on vaccines for infectious disease and cancer, which the companies believe can be attacked with just a few doses of mRNA. And each has already tested its technology on hundreds of patients.

“I would say that mRNA is better suited for diseases where treatment for short duration is sufficiently curative, so the toxicities caused by delivery materials are less likely to occur,” said Katalin Karikó, a pioneer in the field who serves as a vice president at BioNTech.

That makes vaccines the lowest hanging fruit in mRNA, said Franz-Werner Haas, CureVac’s chief corporate officer. “From our point of view, it’s obvious why {Moderna} started there,” he said.

And this:

From the start, Moderna heralded its ability to produce proteins within cells, which could open up a world of therapeutic targets unreachable by conventional drugs. The most revolutionary treatments, which could challenge the multibillion-dollar market for protein therapy, would involve repeated doses of mRNA over many years, so a patient’s body continued to produce proteins to keep disease at bay.

So it is an on going gene therapy that has been marketed as a two shot vaccine with booster shots. It was always known two shots wouldn't be enough.

This whole article is a nugget of information:

“I would say that mRNA is better suited for diseases where treatment for short duration is sufficiently curative, so the toxicities caused by delivery materials are less likely to occur,” said Katalin Karikó, a pioneer in the field who serves as a vice president at BioNTech.

So it is the fucking nanoparticles or lipids that are toxic, as shown in that Japanese toxicity report on rats or mice.

The claims have always been about the mRNA staying in the muscle. Nothing was ever said about the lipid nanoparticles.

I thought those Japanese reports just mapped the spread of the nanoparticles without cell receptors to bind them and transfer the mRNA. Not that they reported any toxicity from them. A lipid is just a fat.

No idea about the specifics. But whatever the thing called a lipid nanoparticle is, it appears to be generally accepted that it was/and or can still be dangerous.

I speed read these and I don't think I'm confusing anything:

"The mRNA-LNP platform’s lipid nanoparticle component used in preclinical vaccine studies is highly inflammatory" - https://www.biorxiv.org/content/10.1101 ... 4.430128v1

"Solid Lipid Nanoparticles for Drug Delivery: Pharmacological and Biopharmaceutical Aspects" - -https://www.frontiersin.org/articles/10.3389/fmolb.2020.587997/full

"Research looks at inflammatory nature of lipid nanoparticle component in mRNA vaccines" - https://www.news-medical.net/news/20210 ... cines.aspx

I generally believe you don't need specialised knowledge to understand things. Those with specialised knowledge(and so nothing else) generally find this view appalling though.

First up - You definitely shouldn't need specialised knowledge to understand most scientific medical stuff. You might need to spend a bit of time getting your head around all the associated stuff to properly understand it tho.

But once it gets to a certain point specialised knowledge helps cos it gets very complicated. I certainly have no specialised knowledge (imo) but I have done studied immunology at uni, tho I dropped out because my work made it hard to do pracs. Anyway....


Hmmmm.....


That is interesting. From what I can tell the dosage appears to be significant. Mice receiving 2.5uG of the stuff didn't react while the reactions got worse for 5uG and 10 uG. Most mice died at 10uG from excessive immune reactions by the looks of things. Lab mice weigh 20-30g, lets say 25g for convenience. That is 40 mice per kilo, or 100uG - 400uG per kilo as the dose range yeah, with 100uG/kg body weight not causing any observable issues and 400uG/kg body weight killing 80% of the mice exposed.

I dunno what the dosage is for humans with the vaccine.

But whatever it is the CDC seems to recommend 6 doses per vial. There doesn't seem to be any other control on that. In country NSW they were able to extract a seventh does using some new technique. So its probably that the vaccine is distributed evenly most of the time among those six (or seven) doses. But what if it isn't evenly distributed sometimes?

That means some people might get large doses at times. Its also possible some people don't get an appropriate dose at other times. It might also not be an issue but who really knows?

Maybe the cases of serious issues with heart inflammation (like Kyle Warner, the MTBer, even tho it seems like in his case he cos an IV injection. He talks about tasting something at the back of his throat immediately after the shot. I know that's a sign of IV not IM injection.) are influenced by that lack of an even distribution in the vial, meaning some doses are more concentrated than others, or have more vaccine in them.

This might also contribute to the waning immunity and to some breakthru cases because if some people are getting "over"doses others will be getting doses under the recommended amount or with none of the vaccine available in them..

But I am speculating. A lot.




Anyway here's the link to the report about extracting the seventh dose from the vial.

https://www1.racgp.org.au/newsgp/clinic ... a-covid-va

[overcoming hope]

Saw the first serious use of the phrase “pandemic of the unboosted” on Reddit. Our host called it

[Belligerent Savant]

.

@TheChiefNerd
·
Pfizer updated their safety and efficacy trial data, showing more deaths in the vaccine group vs placebo and acknowledges myo/pericarditis “serious risks”

https://twitter.com/TheChiefNerd/status ... 34471?s=20

---------------------------------------------------

One Brave ICU Physician Reporting Covid-19 Vaccine Injuries Leads to a Dozen More

11 sworn declarations from physicians across the country reflect the disregard public health agencies have for Covid-19 vaccine safety

One act of bravery begins to snowball. Dr. Patricia Lee “risked it all” to step forward, after being ignored by public health officials, to reveal the serious series of harms she witnessed from Covid-19 vaccines in her intensive care unit. With that one act, my firm has now been contacted by more than a dozen other physicians. Attached are 11 declarations from physicians across the country attesting to serious harms from Covid-19 vaccines.

These physicians, like Dr. Lee, reached out to public health authorities at the CDC, FDA, and NIH for over ten months only to have their concerns dismissed or ignored. These agencies typically respond by saying that VAERS is not showing a safety signal so there is nothing to worry about. If you don’t already know, VAERS is the system that the CDC and FDA say cannot show that a vaccine causes an injury, but yet can show a vaccine is safe. Meaning, heads they win, tails you lose.

Worse, many of these physicians were injured by a Covid-19 vaccine themselves and despite being physicians, the physicians from whom these injured physicians sought treatment also typically dismissed their injuries. And they are physicians seeking help from fellow physicians!

The story most of these physicians tell is like that of Maddie de Garay who, despite being in a wheelchair and needing a feeding tube through her nose, was told it was psychological. These physicians were, incredibly, almost all initially told the same. Only after seeking treatment from physicians that they knew from work or medical school, were many of them believed. If physicians are dismissed as “making it up,” imagine what the average individual without medical knowledge and access must deal with after a Covid-19 vaccine injury.

Public health authorities tell us to trust doctors. If individuals have concerns about the vaccine, they say: “speak with your doctor.” These very doctors are now telling health authorities there is a serious problem. They have been telling these health authorities for months in myriad correspondences. And the 11 declarations attached are likely a small sampling – after all, Dr. Patricia Lee’s letter was only released on this Substack when only had a few hundred subscribers. It nonetheless started a snowball of physicians reaching out with similar stories which is growing by the day.

It should not be that public health authorities listen to physicians only if they parrot their preferred messaging regarding Covid-19 vaccines. To the contrary, physicians should especially be listened to when their clinical experience directly opposes that messaging. But the experience of these physicians, and the many more who have contacted my firm, evidence precisely the opposite is true.

These doctors, like most doctors, are the last individuals that want to admit that a Covid-19 vaccine caused their patients or their own injuries. And they are the last to want to publicly make such an admission. Truly. But reality does not afford them these luxuries. The injuries they report are all too real and devastating. As detailed in the attached declarations (click image below), most of the injured physicians can no longer work or are severely restricted in their ability to work.

The lesson yet again is that civil and individual rights should never be contingent upon a medical procedure. Never. Requiring informed consent – which means giving every American the ability to give or withhold consent without coercion – is the last and final backstop to the dangers that result when we permit the government to decide what must be injected or placed into or onto our bodies. This is no hyperbole as the current state of affairs is that you cannot sue the manufacturers for Covid-19 vaccine injuries, cannot see the data underlying the licensure of the vaccine, cannot discuss Covid-19 vaccine injuries on social media, and cannot say no to the vaccine if you want to keep your job or attend many universities. Whatever your views are on the Covid-19 vaccine itself, every American should reject letting the government decide what medical procedures they must engage in to participate in civil society.

Letter with Physician Declarations to CDC, FDA and NIH

https://www.sirillp.com/wp-content/uplo ... f573b0.pdf

https://aaronsiri.substack.com/p/one-br ... ished=true

[stickdog99]

https://www.israelnationalnews.com/News ... spx/317091

FDA report finds all-cause mortality higher among vaccinated

FDA report shows Pfizer's clinical trials found 24% higher all-cause mortality rate among the vaccinated compared to placebo group.

he clinical trials of Pfizer’s coronavirus vaccine found that the all-cause mortality rate of the vaccinated group was higher than that of the control group, months after the trials were launched, according to a recently released FDA report.

According to the report, which was released by the US Food and Drug Administration to provide background information on its August 2021 decision to grant full approval for the Pfizer-BioNTech coronavirus vaccine after offering limited emergency authorization of use in last December, six months after the vaccine’s clinical trial began, the total number of deaths reported in the vaccinated group was nearly one-quarter higher than the number of deaths in the placebo group.

Just under 22,000 participants were included in each group, with half receiving the coronavirus vaccine, and half receiving a saline solution injection.

The initial results of the clinical trials suggested a high-level of efficacy for the vaccine in preventing symptomatic cases of COVID-19, an in particular, serious illness from COVID – but lacked significant data on all-cause mortality, due to the short time-frame and small number of total deaths.

A follow-up assessment of participants completed on March 13th of this year looked at the overall health outcomes of the trial participants, six months after they received either the COVID vaccine or the saline solution injection.

While Pfizer in July released partial data on the outcomes from the six-month assessment ending March 13th, the new FDA report includes more comprehensive data, and shows a significantly higher number of all-cause fatalities among the vaccinated cohort.

The Pfizer report in late July of this year showed effectively equal all-cause fatality rates between the vaccine and placebo cohorts six months after the tests were conducted, 15 deaths among the nearly 22,000 vaccine recipients, versus 14 deaths among the nearly 22,000 placebo recipients.

Most of the total 29 deaths in both groups were not related to the coronavirus; of the deaths in both groups, three fatalities were listed as being related to the virus; two in the placebo group and one in the vaccinated group.

The FDA report, however, revealed a larger number of deaths by all causes in both groups, with 17 deaths among the control group and 21 in the vaccinated cohort.

The relative difference in all-cause deaths between the two cohorts amounts to 23.5%, though the absolute number of deaths was small – 38 total for all participants in the trial.

However, the FDA justifying its August 2021 approval for the vaccine did not find a link between the vaccine and increased mortality risk, noting that the majority of side-effects, and all common side effects (any reported by more than 10% of recipients) were mild, ranging from fatigue and headache to muscle pain, chills, joint pain, fever, and swelling.

The total number of serious adverse events reported among the placebo and vaccine group were comparable, with 103 events reported among the vaccine group and 117 among the control group, though a break-down and comparison of serious adverse events was not provided.

The FDA report also said that during its initial assessment of the vaccine, no notable patterns linking the vaccine in a 'causal relationship' to specific adverse outcomes were found.

However, the report did say that following the issuance of the emergency use authorization in December 2020, a number of cases of rare heart conditions, including myocarditis and pericarditis, were reported following vaccination, leading the FDA and CDC to identify "serious risks for myocarditis and pericarditis following administration of" the Pfizer vaccine. The risk factor appears to be higher in males under 40, the report added, with boys ages 12 to 17 being especially at risk.

[stickdog99]

FDA Asks Federal Judge to Grant it Until the Year 2076 to Fully Release Pfizer’s COVID-19 Vaccine Data

The fed gov’t shields Pfizer from liability. Gives it billions of dollars. Makes Americans take its product. But won’t let you see the data supporting its safety/efficacy. Who does the gov't work for?

You'd think Pfizer killed JFK.

[stickdog99]

https://alexberenson.substack.com/p/ano ... bout-covid

Another major red flag about Covid vaccines and death

This one coming from data on more than 4 million vaccinated Swedes

Alex Berenson

People appear to die at rates 20 percent or more above normal for weeks after receiving their second Covid vaccine dose, according to data from a huge Swedish study.

The figures are buried in a preprint paper on vaccine effectiveness released last month. The headline finding of the paper was that protection against Covid, including severe cases, plunged after six months.

The researchers did not explicitly examine deaths from all causes - which have risen since the summer in many countries that have highly vaccinated populations.

But on page 32 of the 34-page report, a chart shows that 3,939 of 4.03 million Swedes who received the second dose died less than two weeks later.

(SOURCE: https://papers.ssrn.com/sol3/papers.cfm ... id=3949410)

Over a one-year period, that rate of death would translate into an annual mortality rate of about 2.5 percent a year - 1 person in 40 - almost three times the overall Swedish average. In a typical year, about 1 in 115 Swedes dies.

Of course, that huge gap does not account for an important confounding factor: younger people, who have a much lower risk of death, were less likely to be vaccinated.

But Sweden also provides detailed data on overall deaths nationally, making a crude baseline comparison possible.

That data shows that from an average of about 1,650 Swedes died every week between 2015 and 2019 between April 1 and early August, the period in which almost all of those 4 million Swedes in the study received their second dose. Death rates hardly varied over those years.

(SOURCE: https://www.scb.se/en/finding-statistic ... tatistics/)

In other words, during the spring and summer, Sweden normally has about 3,300 deaths every two weeks - not just in the people who received vaccines, but in all 10.6 million of its people.

So let’s make an incredibly conservative assumption, one that strongly favors the vaccines. (The next couple paragraphs are a bit tricky, but I hope the payoff is worth taking the time to read and think through them.)

Assume that the group of people who received vaccines were so much older and unhealthier than those who didn’t that they would have accounted for every single death in Sweden whether or not they were vaccinated. In other words, assume that even if the vaccines did not exist, every person in Sweden who died would have been part of that group of 4.03 million people the researchers tracked - while not one other person would have died.

In that case, those 4.03 million people “should” have about 3,300 deaths every two weeks. They CANNOT HAVE MORE - because all of Sweden does not have more.

But the vaccines do exist. Those 4.03 million people received them. And in the two weeks after receiving the second vaccine dose, as a group, the researchers reported they had not about 3,300 deaths, but 3,939.

And 3,939 deaths is about 20 percent more deaths than “should” have occurred in those two post-vaccine weeks. Again, the 20 percent figure understates the real gap, because in the real world some deaths will occur in the 6.6 million unvaccinated people too, so the actual baseline number for the vaccinated group is not 3,300 deaths but somewhat lower.

Unfortunately, the researchers did not report any details on the deaths, so it is impossible to know if they are disproportionately cardiovascular. It is also impossible to know whether one particular vaccine was disproportionately linked to deaths. (Sweden used mostly the Pfizer mRNA vaccine, as well as some of AstraZeneca’s DNA/AAV vaccine, which is not available in the United States, and a small amount of Moderna’s mRNA vaccine.)

Of course, it is just possible the extra deaths are due to chance. Or that the handful of elderly Swedes who received vaccines in February and March accounted for a hugely disproportionate number of the post-vaccine deaths. (Because per-week Swedish death rates are higher in the winter, a large number of post-vaccine deaths in those months would somewhat reduce the strength of the signal, though it would still exist.)

But the caveats aside, the Swedish figures offer a very large real-world dataset apparently showing a notable increase in all-cause mortality directly following Covid vaccination.

They are yet another piece of evidence in an increasingly worrying picture - alongside case and anecdotal reports, a known link to heart inflammation in young men, the updated Pfizer clinical trial data revealing a numerical imbalance in deaths in vaccinated people, and most importantly the general rise in all-cause mortality in many countries.

And all of these red flags come for vaccines that - if the Swedish data are correct - may actually raise the risk of Covid infection after about eight months.

Yes, RAISE. See how that black line drops below the zero level on the top chart? That represents negative effectiveness, which is another way to say people who are vaccinated are MORE likely to be infected than those who aren’t.

And, as the second chart shows, effectiveness against severe Covid infection is also spiraling towards zero.



Yet the Biden Administration and governments across Europe continue to try to force more people to take these vaccines.

Why?