Coronavirus Crisis: Main Thread

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Re: Coronavirus Crisis: Main Thread

Postby Elvis » Thu Jan 21, 2021 7:25 pm

Belligerent Savant wrote:So then the commentary by the holocaust survivor can simply be discarded w/out any further assessment!


I was assessing those listed rightwing economists who push austerity. They suck.
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Re: Coronavirus Crisis: Main Thread

Postby mentalgongfu2 » Fri Jan 22, 2021 5:29 am

Mentalgongfu2 said:
Hey, Belligerent Savant. You asked earlier where I live and what I'm seeing in terms of mask wearing, etc. For the record, those answers are already in this thread pages ago, should you care to read what other people have to say. I don' think you really do, so I'm not going to repeat myself. Maybe I'm wrong, and you're not solely intent on promoting your existing conclusion. Should that actually be the case, all you have to do is scroll back to April or thereabouts. Not much has changed here since then. By the time anyone in authority started to take seriously death and illness and hospital ICU overload, there weren't many people who could be persuaded away from what they had already concluded.


Belligerent Savant said:
This thread is currently 136 pages. Most of these pages accumulated AFTER April. To expect i'd recall your posting from almost a year ago is silly, if serious.

You can attempt to besmirch my character all you want. The data is what it is, and eventually, hopefully sooner rather than later, policy will promptly adjust to reflect actual risk rather than grossly inflated risk.

I have replied to and addressed many comments here, so clearly i read what others type.


Mayhaps my wording was unclear. I don't expect you to recall anything I said a year ago. I was telling you where it is because you asked about. I told you exactly where to find it, as close as I can get without citing a page number from the thread. Should you care to find my personal observations, after spending time in the hospital near what we in the USA tend to now consider "the beginning," I thought I narrowed it quite well. Around the start of April. Not the entirety of "AFTER April" wherein much of the thread is contained. That certainly does not require intense searching skills, to look at dates of posts and move to new pages. I do it all the time.

I understand, given my saucy attitude, if you don't want to do it. But let us not pretend that I put you on a needle in a haystack hunt. I will openly admit that I could try harder, but without attempting to besmirch you, it is clear to me you have a made up mind on this subject. Like a lake covered in ice, no matter how many stones I throw at it, they will simply bounce off. And my arm is tired. So if you're legitimately curious about what is happening where I am (or in this specific instance, what was happening almost a year ago, which ain't much different) you have access to my full personal story of my experience, which I posted in some detail. Things being as they are, it doesn't really matter, as I don't expect your opinion to shift. Sometimes a cigar is just a cigar.
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Re: Coronavirus Crisis: Main Thread

Postby Belligerent Savant » Fri Jan 22, 2021 3:55 pm

.

The below update is COUNTER to all prior 'official' guidance and messaging.

Fortuitous timing (as forecast by BelSav in this very thread, a couple months or so ago, and surely by anyone else sifting through the fog), now that the orange blight is out of office.

Directly from the WHO:

https://www.who.int/news/item/20-01-202 ... rs-2020-05

WHO guidance Diagnostic testing for SARS-CoV-2 states that careful interpretation of weak positive results is needed (1). The cycle threshold (Ct) needed to detect virus is inversely proportional to the patient’s viral load. Where test results do not correspond with the clinical presentation, a new specimen should be taken and retested using the same or different NAT technology.

WHO reminds IVD users that disease prevalence alters the predictive value of test results; as disease prevalence decreases, the risk of false positive increases (2). This means that the probability that a person who has a positive result (SARS-CoV-2 detected) is truly infected with SARS-CoV-2 decreases as prevalence decreases, irrespective of the claimed specificity.

Most PCR assays are indicated as an aid for diagnosis, therefore, health care providers must consider any result in combination with timing of sampling, specimen type, assay specifics, clinical observations, patient history, confirmed status of any contacts, and epidemiological information.




The guidance warned against diagnosing someone as having the virus just because one tests positive if the individual does not present with symptoms of COVID-19. It also warned about the high risk of false positives: “The cycle threshold (Ct) needed to detect virus is inversely proportional to the patient’s viral load. Where test results do not correspond with the clinical presentation, a new specimen should be taken and retested using the same or different NAT technology.”

“As disease prevalence decreases, the risk of false positive increases. The probability that a person who has a positive result (SARS-CoV-2 detected) is truly infected with SARS-CoV-2 decreases as prevalence decreases, irrespective of the claimed specificity,” per the WHO.

It also describes PCR tests merely as an “aid for diagnosis” and did not place any greater weight upon the results of PCR tests. “Most PCR assays are indicated as an aid for diagnosis, therefore, health care providers must consider any result in combination with timing of sampling, specimen type, assay specifics, clinical observations, patient history, confirmed status of any contacts, and epidemiological information.”

The new guidance for assessing the results of PCR COVID tests effectively means that there are additional steps to be taken before reporting that someone has tested positive for the virus. The WHO notes that “a new specimen should be taken and retested” and further stipulates that “health care” workers should weigh up the test result alongside real-world information, such as symptoms or “clinical observations,” and contact with any other infected individuals.
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Re: Coronavirus Crisis: Main Thread

Postby dada » Fri Jan 22, 2021 4:47 pm

WHO is the great reset?

five words general discussion brings to mind today
Both his words and manner of speech seemed at first totally unfamiliar to me, and yet somehow they stirred memories - as an actor might be stirred by the forgotten lines of some role he had played far away and long ago.
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Sabine Hossenfelder (note: Oct 28, 2020)

Postby JackRiddler » Sat Jan 23, 2021 11:36 am

I would not say it's counter to all prior... rather it returns us to pretty much what was the common-sense consensus up to March or April.

Meanwhile, I give this video a lot of wows for sobriety, precision, careful definition of terms, and delineation of which questions are of science and which of values. (I wish we had more thinkers and fewer agenda-blabbers of all kinds in our mix of posted authorities here, but anyway...) And it's short. Watch. Also found the transcript on her blog...


https://www.youtube.com/watch?v=NENhBmN_tps

Wednesday, October 28, 2020
http://backreaction.blogspot.com/2020/1 ... mbers.html

Herd Immunity, Facts and Numbers


Today, I have a few words to say about herd immunity because there’s very little science in the discussion about it. I also want to briefly comment on the Great Barrington Declaration and on the conversation about it that we are not having.

First things first, herd immunity refers to that stage in the spread of a disease when a sufficient fraction of the population has become immune to the pathogen so that transmission will be suppressed. It does not mean that transmission stops, it means that on the average one infected person gives the disease to less than one new person, so outbreaks die out, instead of increasing.

It’s called “herd immunity” because it was first observed about a century ago in herds of sheep and, in some ways we’re not all that different from sheep.

Now, herd immunity is the only way a disease that is not contained will stop spreading. It can be achieved either by exposure to the live pathogen or by vaccination. However, in the current debate about the pursuit of herd immunity in response to the ongoing COVID outbreak, the term “herd immunity” has specifically been used to refer to herd immunity achieved by exposure to the virus, instead of waiting for a vaccine.

Second things second, when does a population reach herd immunity? The brief answer is, it’s complicated. This should not surprise you because whenever someone claims the answer to a scientific question is simple they either don’t know what they’re talking about, or they’re lying. There is a simple answer to the question when a population reaches herd immunity. But it does not tell the whole story.

This simple answer is that one can calculate the fraction of people who must be immune for herd immunity from the basic reproduction number R_0 as 1- 1/R_0.

Why is that? It’s because, R_0 tells you how many new people one infected person infects on the average. But the ones who will get ill are only those which are not immune. So if 1-1/R_0 is the fraction of people who are immune, then the fraction of people who are not immune is 1/R_0.

This then means that average number of susceptible people that one infected person reaches is R_0 * 1/R_0 which is 1. So, if the fraction of immune people has reached 1 – 1/R_0, then one infected person will on the average only pass on the disease to one other person, meaning at any level of immunity above 1 – 1/R_0, outbreaks will die out.

R_0 for COVID has been estimated with 2 to 3, meaning that the fraction of people who must have had the disease for herd immunity would be around 50 to 70 percent. For comparison, R_0 of the 1918 Spanish influenza has been estimated with 1.4 to 2.8, so that’s comparable to COVID, and R_0 of measles is roughly 12 to 18, with a herd immunity threshold of about 92-95%. Measles is pretty much the most contagious disease known to mankind.

That was the easy answer.

Here’s the more complicated but also more accurate answer. R_0 is not simply a property of the disease. It’s a number that quantifies successful transmission, and therefore depends on what measures people take to protect themselves from infection, such as social distancing, wearing masks, and washing hands. This is why epidemiologists use in their models instead an “effective R” coefficient that can change with time and with people’s habits. Roughly speaking this means that if we would all be very careful and very reasonable, then herd immunity would be easier to achieve.

But that R can change is not the biggest problem with estimating herd immunity. The biggest problem is that the simple estimate I just talked about assumes that everybody is equally likely to meet other people, which is just not the case in reality.

In realistic populations under normal circumstances, some people will have an above average number of contacts, and others below average. Now, people who have many contacts are likely to contribute a lot to the spread of the disease, but they are also likely to be among the first ones to contract the disease, and therefore become immune early on.

This means, if you use information about the mobility patterns, social networks, and population heterogeneity, the herd immunity threshold is lower because the biggest spreaders are the first to stop spreading. Taking this into account, some researchers have estimated the COVID herd immunity threshold to be more like 40% or in some optimistic cases even below 20%.

How reliable are these estimates? To me it looks like these estimates are based on more or less plausible models with little empirical data to back them up. And plausible models are the ones one should be especially careful with.

So what do the data say? Unfortunately, so far not much. The best data on herd immunity so far come from an antibody study in the Brazilian city of Manaus. That’s one of the largest cities in Brazil, with an estimated population of two point one million.

According to data from the state government, there have been about fifty five thousand COVID cases and two thousand seven hundred COVID fatalities in Manaus. These numbers likely underestimate the true number of infected and deceased people because the Brazilians have not been testing a lot. Then again, most countries did not have sufficient testing during the first wave.

If you go by the reported numbers, then about two point seven percent of the population in Manaus tested positive for COVID at some point during the outbreak. But the study which used blood donations collected during this time found that about forty-four percent of the population developed antibodies in the first three months of the outbreak.

After that, the infections tapered off without interventions. The researchers estimate the total number of people who eventually developed antibodies with sixty-six percent. The researchers claim that’s a sign for herd immunity. Please check the information below the video for references.

The number from this Brazilian study, about 44 to 66 percent seems consistent with the more pessimistic estimates for the COVID herd immunity threshold. But what it took to get there is not pretty.

2700 dead of about two million that’s more than one in a thousand. Hospitals run out of intensive care units, people were dying in the corridors, the city was scrambling to find ways to bury the dead quickly enough. And that’s even though the population of Manaus is pretty young; just six percent are older than sixty years. For comparison, in the United States, about 20% are above sixty years of age, and older people are more likely to die from the disease.

There are other reasons one cannot really compare Manaus with North America or Europe. Their health care system was working at almost full capacity even before the outbreak, and according to data from the world bank, in the Brazilian state which Manaus belongs to, the state of Amazonas, about 17% of people live below the poverty line. Also, most of the population in Manaus did not follow social distancing rules and few of them wore masks. These factors likely contributed to the rapid spread of the disease.

And I should add that the paper with the antibody study in Manaus has not yet been peer reviewed. There are various reasons why the people who donated blood may not be representative for the population. The authors write they corrected for this, but it remains to be seen what the reviewers think.

You probably want to know now how close we are to reaching herd immunity. The answer is, for all can tell, no one knows. That’s because, even leaving aside that we have no reliable estimates on the herd immunity threshold, we do not how many people have developed immunity to COVID.

In Manaus, the number of people who developed antibodies was more than twenty times higher than the number of those who tested positive. As of date in the United States about eight point five million people tested positive for COVID. The total population is about 330 Million.

This means about 2.5% of Americans have demonstrably contracted the disease, a rate that just by number is similar to the rate in Manaus, though Manaus got there faster with devastating consequences. However, the Americans are almost certainly better at testing and one cannot compare a sparsely populated country, like the United States, with one densely populated city in another country. So, again, it’s complicated.

For the Germans here, in Germany so far about 400,000 people have tested positive. That’s about 0.5 percent of the population.

And then, I should not forget to mention that antibodies are not the only way one can develop immunity. There is also T-cell immunity, that is basically a different defense mechanism of the body. The most relevant difference for the question of herd immunity is that it’s much more difficult to test for T-cell immunity. Which is why there are basically no data on it. But there are pretty reliable data by now showing that immunity to COVID is only temporary, antibody levels fall after a few months, and reinfections are possible, though it remains unclear how common they will be.

So, in summary: Estimates for the COVID herd immunity threshold range from roughly twenty percent to seventy percent, there are pretty much no data to make these estimates more accurate, we have no good data on how many people are presently immune, but we know reinfection is possible after a couple of months.

Let us then talk about the Great Barrington Declaration. The Great Barrington Declaration is not actually Great, it was merely written in place called Great Barrington. The declaration was formulated by three epidemiologists, and according to claims on the website, it has since been signed by more than eleven thousand medical and public health scientists.

The supporters of the declaration disapprove of lockdown measures and instead argue for an approach they call Focused Protection. In their own words:
“The most compassionate approach that balances the risks and benefits of reaching herd immunity, is to allow those who are at minimal risk of death to live their lives normally to build up immunity to the virus through natural infection, while better protecting those who are at highest risk. We call this Focused Protection.”

The reaction by other scientists and the media has been swift and negative. The Guardian called the Barrington Declaration “half baked” “bad science” and “a folly”. A group of scientists writing for The Lancet called it a “dangerous fallacy unsupported by scientific evidence”, the US American infectious disease expert Fauci called it “total nonsense,” and John Barry, writing for the New York Times, went so far to suggest it be called “mass murder” instead of herd immunity. Though they later changed the headline.

Some of the criticism focused on the people who wrote the declaration, or who they might have been supported by. These are ad hominem attacks that just distract from the science, so I don’t want to get into this.

The central element of the criticism is that the Barrington Declaration is vague on how the “Focused Protection” is supposed to work. This is a valid criticism. The declaration left it unclear just to how identify those at risk and how to keep them efficiently apart from the rest of the population, which is certainly difficult to achieve. But of course if no one is thinking about how to do it, there will be no plan for how to do it.

Why am I telling you this? Because I think all these commentators missed the point of the Barrington Declaration. Let us take this quote from an opinion piece in the Guardian in which three public health scientists commented on the idea of focused protection:

“It’s time to stop asking the question “is this sound science?” We know it is not.”

It’s right that arguing for focused protection is not sound science, but that is not because it’s not sound, it’s because it’s not science. It’s a value decision.

The authors of the Great Barrington Declaration point out, entirely correctly, that we are in a situation where we have only bad options. Lockdown measures are bad, pursuing natural herd immunity is also bad.

The question is, which is worse, and just what do you mean by “worse”. This is the decision that politicians are facing now and it is not obvious what is the best strategy. This decision must be supported by data for the consequences of each possible path of action. So we need to discuss not only how many people die from COVID and what the long-term health problems may be, but also how lockdowns, social distancing, and economic distress affect health and health care. We need proper risk estimates with uncertainties. We do not need scientists who proclaim that science tells us what’s the right thing to do.

I hope that this brief survey of the literature on herd immunity was helpful for you.
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Re: Coronavirus Crisis: Main Thread

Postby Belligerent Savant » Sun Jan 24, 2021 1:26 pm

^^^^^^^^

Thanks for sharing this, Jack.

The entire transcription is worth reading, but the 2 bits I'd like to highlight are:


Some of the criticism focused on the people who wrote the declaration, or who they might have been supported by. These are ad hominem attacks that just distract from the science, so I don’t want to get into this.

...

This is the decision that politicians are facing now and it is not obvious what is the best strategy. This decision must be supported by data for the consequences of each possible path of action. So we need to discuss not only how many people die from COVID and what the long-term health problems may be, but also how lockdowns, social distancing, and economic distress affect health and health care. We need proper risk estimates with uncertainties. We do not need scientists who proclaim that science tells us what’s the right thing to do.


The first quoted line ties back to the tendency by some to 'throw the baby out with the bathwater', as exemplified in a prior contribution upthread.

With respect to the 2nd quoted excerpt, I underlined "discuss" because there has been NO discussion by decision-makers with their constituents on path-forward plans -- let alone discussions in a public forum allowing for differing viewpoints/action plans to be aired and/or fleshed out prior to ratifying as mandates. This is a problem for a number of reasons that needn't be expounded on here.

Arguably, there wasn't time for 'discussion' when this virus first hit in the earlier months of 2020. But there's been ample time to do so since then.

The other reason I quoted the latter bit, above, is that it correlates directly with the below tweet excerpts. I pasted only a few of the ~21 informative charts/data points available when clicking on the tweet link below, further expounding on the topic:

Image

https://twitter.com/the_brumby/status/1 ... 6704795648

ALSO:

a birdie informed me of the twitter handle of a former colleague of ours. I share a sampling below -- hopefully he won't mind.

Image

https://mobile.twitter.com/mmaccruiskeen
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Re: Coronavirus Crisis: Main Thread

Postby dada » Sun Jan 24, 2021 3:21 pm

There are pre-existing structural inequalities that are exacerbated by the response to the virus.

Everyone agrees, hypothetically. I think the argument is whether critique of the response belongs into a critique of Capitalism, or not. If not, it seems to become further evidence of the machinations orchestrated by a globalist liberal elite. Food for Q.
Both his words and manner of speech seemed at first totally unfamiliar to me, and yet somehow they stirred memories - as an actor might be stirred by the forgotten lines of some role he had played far away and long ago.
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Re: Coronavirus Crisis: Main Thread

Postby Belligerent Savant » Sun Jan 24, 2021 6:50 pm

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Re: Coronavirus Crisis: Main Thread

Postby Belligerent Savant » Sun Jan 24, 2021 8:57 pm

.

Worth reading in full. For brevity, I will include portions of the Abstract and Conclusion, below.

Note: this article assumes all official tallies ("case" counts and death counts) at face-value, as the focus of this piece is elsewhere.

https://academic.oup.com/jlb/advance-ar ... 64/5912724


COVID-19 emergency measures and the impending authoritarian pandemic

Stephen Thomson, Eric C Ip Author Notes

Journal of Law and the Biosciences, https://doi.org/10.1093/jlb/lsaa064
Published:
29 September 2020

ABSTRACT

...as this Article demonstrates—with diverse examples drawn from across the world—there are unmistakable regressions into authoritarianism in governmental efforts to contain the virus. Despite the unprecedented nature of this challenge, there is no sound justification for systemic erosion of rights-protective democratic ideals and institutions beyond that which is strictly demanded by the exigencies of the pandemic. A Wuhan-inspired all-or-nothing approach to viral containment sets a dangerous precedent for future pandemics and disasters, with the global copycat response indicating an impending ‘pandemic’ of a different sort, that of authoritarianism. With a gratuitous toll being inflicted on democracy, civil liberties, fundamental freedoms, healthcare ethics, and human dignity, this has the potential to unleash humanitarian crises no less devastating than COVID-19 in the long run.

VI. CONCLUSION

...Under such exceptional circumstances, governments can harness authority that is normally unavailable in the absence of explicit, ongoing, legislative approval, once a legal or de facto state of public health emergency is declared.250 Sometimes, restraints on government power anchored in individual rights are overridden or relaxed in light of the exigent situation.251 The culture of fear engendered by alarmist pandemic measures and narratives nevertheless secures high levels of obedience among populations, even in otherwise liberal democratic states.

However, the exercise of emergency powers outside the ordinary structures of checks and balances can be justified only if the relevant harm cannot be defused by way of ordinary procedures.252 The use of extreme public health emergency measures to combat pandemics underscores an ethical tension between individual interests and the perceived collective good, the resolution of which requires demonstration that restrictions on individual rights and freedoms are necessary and proportionate to the attainment of stated public health objectives.253 The creation and invocation of emergency powers can set a perilous example for future public health emergencies, with instances of ‘temporary’ emergency measures in place for unjustifiably long periods being found throughout world history.254

As this Article has demonstrated, a transnational constitutional pandemic is coming of age: regressions in the thinking of public health authorities to one of containment of COVID-19 at all costs, including its prioritization over matters that impinge on healthcare ethics and human dignity, are effectuating the imposition of disproportionate, uncompromising emergency responses. These same responses are becoming, or on the verge of becoming, a catalyst or agent for a renewed authoritarianization in both democracies and non-democracies—a constitutional pandemic of devastating magnitude in its own right. An unwarranted authoritarian erosion of civil liberties in the name of protecting public health is counter-productive and self-defeating, as it could trigger an overall decline in public health in the long run, and must not be added to the enormous social and economic costs already incurred, as yet with no end in sight. COVID-19 containment measures, like all public health emergency interventions, must always be based on ongoing scientific risk assessments, a commitment on the part of the state to provide its citizens with tolerably safe environments, rigorous enforcement of due process and procedural justice, and implementation of emergency measures that are the least restrictive to constitutionally enshrined rights and liberties.255

An authoritarian response to a biomedical pandemic is not, and never will be, a humanitarian solution.

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Re: Sabine Hossenfelder (note: Oct 28, 2020)

Postby stickdog99 » Mon Jan 25, 2021 5:58 pm

JackRiddler » 23 Jan 2021 15:36 wrote:I would not say it's counter to all prior... rather it returns us to pretty much what was the common-sense consensus up to March or April.

Meanwhile, I give this video a lot of wows for sobriety, precision, careful definition of terms, and delineation of which questions are of science and which of values. (I wish we had more thinkers and fewer agenda-blabbers of all kinds in our mix of posted authorities here, but anyway...) And it's short. Watch. Also found the transcript on her blog...


https://www.youtube.com/watch?v=NENhBmN_tps

Wednesday, October 28, 2020
http://backreaction.blogspot.com/2020/1 ... mbers.html

Herd Immunity, Facts and Numbers


Today, I have a few words to say about herd immunity because there’s very little science in the discussion about it. I also want to briefly comment on the Great Barrington Declaration and on the conversation about it that we are not having.

First things first, herd immunity refers to that stage in the spread of a disease when a sufficient fraction of the population has become immune to the pathogen so that transmission will be suppressed. It does not mean that transmission stops, it means that on the average one infected person gives the disease to less than one new person, so outbreaks die out, instead of increasing.

It’s called “herd immunity” because it was first observed about a century ago in herds of sheep and, in some ways we’re not all that different from sheep.

Now, herd immunity is the only way a disease that is not contained will stop spreading. It can be achieved either by exposure to the live pathogen or by vaccination. However, in the current debate about the pursuit of herd immunity in response to the ongoing COVID outbreak, the term “herd immunity” has specifically been used to refer to herd immunity achieved by exposure to the virus, instead of waiting for a vaccine.

Second things second, when does a population reach herd immunity? The brief answer is, it’s complicated. This should not surprise you because whenever someone claims the answer to a scientific question is simple they either don’t know what they’re talking about, or they’re lying. There is a simple answer to the question when a population reaches herd immunity. But it does not tell the whole story.

This simple answer is that one can calculate the fraction of people who must be immune for herd immunity from the basic reproduction number R_0 as 1- 1/R_0.

Why is that? It’s because, R_0 tells you how many new people one infected person infects on the average. But the ones who will get ill are only those which are not immune. So if 1-1/R_0 is the fraction of people who are immune, then the fraction of people who are not immune is 1/R_0.

This then means that average number of susceptible people that one infected person reaches is R_0 * 1/R_0 which is 1. So, if the fraction of immune people has reached 1 – 1/R_0, then one infected person will on the average only pass on the disease to one other person, meaning at any level of immunity above 1 – 1/R_0, outbreaks will die out.

R_0 for COVID has been estimated with 2 to 3, meaning that the fraction of people who must have had the disease for herd immunity would be around 50 to 70 percent. For comparison, R_0 of the 1918 Spanish influenza has been estimated with 1.4 to 2.8, so that’s comparable to COVID, and R_0 of measles is roughly 12 to 18, with a herd immunity threshold of about 92-95%. Measles is pretty much the most contagious disease known to mankind.

That was the easy answer.

Here’s the more complicated but also more accurate answer. R_0 is not simply a property of the disease. It’s a number that quantifies successful transmission, and therefore depends on what measures people take to protect themselves from infection, such as social distancing, wearing masks, and washing hands. This is why epidemiologists use in their models instead an “effective R” coefficient that can change with time and with people’s habits. Roughly speaking this means that if we would all be very careful and very reasonable, then herd immunity would be easier to achieve.

But that R can change is not the biggest problem with estimating herd immunity. The biggest problem is that the simple estimate I just talked about assumes that everybody is equally likely to meet other people, which is just not the case in reality.

In realistic populations under normal circumstances, some people will have an above average number of contacts, and others below average. Now, people who have many contacts are likely to contribute a lot to the spread of the disease, but they are also likely to be among the first ones to contract the disease, and therefore become immune early on.

This means, if you use information about the mobility patterns, social networks, and population heterogeneity, the herd immunity threshold is lower because the biggest spreaders are the first to stop spreading. Taking this into account, some researchers have estimated the COVID herd immunity threshold to be more like 40% or in some optimistic cases even below 20%.

How reliable are these estimates? To me it looks like these estimates are based on more or less plausible models with little empirical data to back them up. And plausible models are the ones one should be especially careful with.

So what do the data say? Unfortunately, so far not much. The best data on herd immunity so far come from an antibody study in the Brazilian city of Manaus. That’s one of the largest cities in Brazil, with an estimated population of two point one million.

According to data from the state government, there have been about fifty five thousand COVID cases and two thousand seven hundred COVID fatalities in Manaus. These numbers likely underestimate the true number of infected and deceased people because the Brazilians have not been testing a lot. Then again, most countries did not have sufficient testing during the first wave.

If you go by the reported numbers, then about two point seven percent of the population in Manaus tested positive for COVID at some point during the outbreak. But the study which used blood donations collected during this time found that about forty-four percent of the population developed antibodies in the first three months of the outbreak.

After that, the infections tapered off without interventions. The researchers estimate the total number of people who eventually developed antibodies with sixty-six percent. The researchers claim that’s a sign for herd immunity. Please check the information below the video for references.

The number from this Brazilian study, about 44 to 66 percent seems consistent with the more pessimistic estimates for the COVID herd immunity threshold. But what it took to get there is not pretty.

2700 dead of about two million that’s more than one in a thousand. Hospitals run out of intensive care units, people were dying in the corridors, the city was scrambling to find ways to bury the dead quickly enough. And that’s even though the population of Manaus is pretty young; just six percent are older than sixty years. For comparison, in the United States, about 20% are above sixty years of age, and older people are more likely to die from the disease.

There are other reasons one cannot really compare Manaus with North America or Europe. Their health care system was working at almost full capacity even before the outbreak, and according to data from the world bank, in the Brazilian state which Manaus belongs to, the state of Amazonas, about 17% of people live below the poverty line. Also, most of the population in Manaus did not follow social distancing rules and few of them wore masks. These factors likely contributed to the rapid spread of the disease.

And I should add that the paper with the antibody study in Manaus has not yet been peer reviewed. There are various reasons why the people who donated blood may not be representative for the population. The authors write they corrected for this, but it remains to be seen what the reviewers think.

You probably want to know now how close we are to reaching herd immunity. The answer is, for all can tell, no one knows. That’s because, even leaving aside that we have no reliable estimates on the herd immunity threshold, we do not how many people have developed immunity to COVID.

In Manaus, the number of people who developed antibodies was more than twenty times higher than the number of those who tested positive. As of date in the United States about eight point five million people tested positive for COVID. The total population is about 330 Million.

This means about 2.5% of Americans have demonstrably contracted the disease, a rate that just by number is similar to the rate in Manaus, though Manaus got there faster with devastating consequences. However, the Americans are almost certainly better at testing and one cannot compare a sparsely populated country, like the United States, with one densely populated city in another country. So, again, it’s complicated.

For the Germans here, in Germany so far about 400,000 people have tested positive. That’s about 0.5 percent of the population.

And then, I should not forget to mention that antibodies are not the only way one can develop immunity. There is also T-cell immunity, that is basically a different defense mechanism of the body. The most relevant difference for the question of herd immunity is that it’s much more difficult to test for T-cell immunity. Which is why there are basically no data on it. But there are pretty reliable data by now showing that immunity to COVID is only temporary, antibody levels fall after a few months, and reinfections are possible, though it remains unclear how common they will be.

So, in summary: Estimates for the COVID herd immunity threshold range from roughly twenty percent to seventy percent, there are pretty much no data to make these estimates more accurate, we have no good data on how many people are presently immune, but we know reinfection is possible after a couple of months.

Let us then talk about the Great Barrington Declaration. The Great Barrington Declaration is not actually Great, it was merely written in place called Great Barrington. The declaration was formulated by three epidemiologists, and according to claims on the website, it has since been signed by more than eleven thousand medical and public health scientists.

The supporters of the declaration disapprove of lockdown measures and instead argue for an approach they call Focused Protection. In their own words:
“The most compassionate approach that balances the risks and benefits of reaching herd immunity, is to allow those who are at minimal risk of death to live their lives normally to build up immunity to the virus through natural infection, while better protecting those who are at highest risk. We call this Focused Protection.”

The reaction by other scientists and the media has been swift and negative. The Guardian called the Barrington Declaration “half baked” “bad science” and “a folly”. A group of scientists writing for The Lancet called it a “dangerous fallacy unsupported by scientific evidence”, the US American infectious disease expert Fauci called it “total nonsense,” and John Barry, writing for the New York Times, went so far to suggest it be called “mass murder” instead of herd immunity. Though they later changed the headline.

Some of the criticism focused on the people who wrote the declaration, or who they might have been supported by. These are ad hominem attacks that just distract from the science, so I don’t want to get into this.

The central element of the criticism is that the Barrington Declaration is vague on how the “Focused Protection” is supposed to work. This is a valid criticism. The declaration left it unclear just to how identify those at risk and how to keep them efficiently apart from the rest of the population, which is certainly difficult to achieve. But of course if no one is thinking about how to do it, there will be no plan for how to do it.

Why am I telling you this? Because I think all these commentators missed the point of the Barrington Declaration. Let us take this quote from an opinion piece in the Guardian in which three public health scientists commented on the idea of focused protection:

“It’s time to stop asking the question “is this sound science?” We know it is not.”

It’s right that arguing for focused protection is not sound science, but that is not because it’s not sound, it’s because it’s not science. It’s a value decision.

The authors of the Great Barrington Declaration point out, entirely correctly, that we are in a situation where we have only bad options. Lockdown measures are bad, pursuing natural herd immunity is also bad.

The question is, which is worse, and just what do you mean by “worse”. This is the decision that politicians are facing now and it is not obvious what is the best strategy. This decision must be supported by data for the consequences of each possible path of action. So we need to discuss not only how many people die from COVID and what the long-term health problems may be, but also how lockdowns, social distancing, and economic distress affect health and health care. We need proper risk estimates with uncertainties. We do not need scientists who proclaim that science tells us what’s the right thing to do.

I hope that this brief survey of the literature on herd immunity was helpful for you.


What I get from this is that we need better data. Of course we need better data. We are now almost a year into this crisis, and still we have not taken more than a hundred simple and obvious necessary measures to ensure that we can get the better data we need, including the data we need on the relative success and/or negative side effects of the various experimental vaccines we are rolling out right now.

So why haven't we instituted best practices on COVID testing and all manners of COVID data gathering more than 10 months after this crisis began?

Why are we instead still flying blind and using articles of faith instead of gathering the critical data we need on the effectiveness of practices such as face masking, hand washing, and social distancing at slowing the transmission of an airborne respiratory virus?
Last edited by stickdog99 on Mon Jan 25, 2021 7:30 pm, edited 1 time in total.
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Re: Coronavirus Crisis: Main Thread

Postby stickdog99 » Mon Jan 25, 2021 6:02 pm

dada » 24 Jan 2021 19:21 wrote:There are pre-existing structural inequalities that are exacerbated by the response to the virus.

Everyone agrees, hypothetically. I think the argument is whether critique of the response belongs into a critique of Capitalism, or not. If not, it seems to become further evidence of the machinations orchestrated by a globalist liberal elite. Food for Q.


Critique of capitalism or critique of the hypercapitalist, winner-take-all system of oligopolies that we currently enjoy?
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Re: Coronavirus Crisis: Main Thread

Postby JackRiddler » Mon Jan 25, 2021 7:01 pm

Though a rare acknowledgment of the obvious from this outlet, the Newspeak wrapping really pissed me off:

Pandemic Takes Heavy Toll on Children and Students’ Physical and Mental Health
JAN 25, 2021

In Texas, Dallas County has reversed a plan to prioritize vaccinating people in its hardest-hit areas, largely communities of color, after state authorities threatened to cut their supply, saying it did not meet official distribution guidelines.

The pandemic is continuing to take a severe toll on children and young people. A new report finds one in six households with children have not been getting enough to eat. School closures have also meant many young people are not getting essential mental and emotional support from teachers and therapists.

In Nevada, a surge in student suicides has led officials in Las Vegas to move toward reopening schools, even with the risk of staff and students becoming infected with COVID-19.


"The pandemic" is doing that? (I know we have members here who will argue, yes, it's the primary cause since it forces these measures as necessities.)

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Re: Coronavirus Crisis: Main Thread

Postby stickdog99 » Mon Jan 25, 2021 7:26 pm

JackRiddler » 25 Jan 2021 23:01 wrote:Though a rare acknowledgment of the obvious from this outlet, the Newspeak wrapping really pissed me off:

Pandemic Takes Heavy Toll on Children and Students’ Physical and Mental Health
JAN 25, 2021

In Texas, Dallas County has reversed a plan to prioritize vaccinating people in its hardest-hit areas, largely communities of color, after state authorities threatened to cut their supply, saying it did not meet official distribution guidelines.

The pandemic is continuing to take a severe toll on children and young people. A new report finds one in six households with children have not been getting enough to eat. School closures have also meant many young people are not getting essential mental and emotional support from teachers and therapists.

In Nevada, a surge in student suicides has led officials in Las Vegas to move toward reopening schools, even with the risk of staff and students becoming infected with COVID-19.


"The pandemic" is doing that? (I know we have members here who will argue, yes, it's the primary cause since it forces these measures as necessities.)

.


Nice catch. The pandemic itself is not taking much of a toll on children.
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Re: Coronavirus Crisis: Main Thread

Postby stickdog99 » Tue Jan 26, 2021 5:39 pm

https://www.sacbee.com/news/coronavirus ... 48595.html

Northern California sheriff’s office defends posting death of COVID vaccine recipient

California state health leaders on Monday said they have joined a review of the unusual death last week of a person in Placer County shortly after receiving a COVID-19 vaccine, describing the case as “complex,” but saying they have not determined if there is link between the vaccine and the death.

“We are working closely with the coroner to determine the details around the death,” state health official Dr. Mark Ghaly said during a Monday press briefing on COVID-19 issues. He called the case complex and “worth further investigation,” but declined to offer further details. ...

The statement notes that “reports surrounding the cause of death are premature” pending that investigation, meaning there has been no indication that the death was connected to the recently administered vaccine dose. Leading health officials warn that people — especially older people, the bulk of vaccine recipients in the current phase of California’s roll out — die all the time of various causes, and that deaths occurring the same day as a vaccine dose are not indicative of a link.

That reality has prompted swarms of social media users to take to comment sections to criticize the Placer County Sheriff’s Office for posting the statement. They express worry that, regardless of the disclaimer about a cause of death, the post will feed skepticism and misconceptions about COVID-19 vaccines, which clinical trial data from Pfizer and Moderna have shown to be safe and effective.

The Sheriff’s Office, and many others in a divided Facebook comments section, defended the announcement as an effort to maintain transparency about what a sheriff’s spokesperson called a “unique situation.” The person who died had tested positive for COVID-19 in late December and died “several hours” after receiving a vaccine dose, the Placer statement said.

Placer sheriff’s spokeswoman Angela Musallam said Monday morning the department will release another statement once an autopsy is completed, but declined to say when that is expected.

She defended her department’s release of the information prior to knowing whether the death was connected to the vaccine, saying it was done in an effort to be open with the public, especially during an era when the trust between the public and government officials has eroded.

“This is a unique situation for us in Placer County. We value transparency. It’s best to be transparent,” Musallam said.

Musallam declined to give the person’s age.

In a separate follow-up statement, Placer County’s Public Health department wrote: “Our thoughts are with the family of the deceased. We take these instances seriously which is why we are working with our government partners to investigate the cause.

“We are working collaboratively and will continue to use data and science to determine how to proceed.”

The initial death announcement was posted as a news release on the Placer County website and as a Facebook post by the Sheriff’s Office on Saturday afternoon.

The latter drew a huge amount of attention, gaining nearly 2,800 comments and more than 3,000 “shares” on Facebook within 48 hours — far more than typical for the agency’s posts.

One word popped up often in user comments: “Irresponsible.”

“If investigation is still pending, wait until you have all the facts,” one of the top-engaged comments reads. “This post creates fear and questions. It’s not OK. Why would you post this vague and terrifying information?”


...

Some infectious disease experts have harshly criticized agencies quickly reporting deaths of vaccine recipients prior to full investigation, saying this opens the door for anti-vaccine groups to spread misinformation.

“You get one chance to make a first impression,” said epidemiologist Dr. Michael Osterholm, a member of President Joe Biden’s transition advisory board, according to a recent story from CNN. “Even if we come back later and say, ‘No, (the deaths) had nothing to do with vaccination, it was coronary artery disease,’ the damage has already been done.”


The Placer County death made local, national and international headlines almost immediately. From Fox News to Xinhua News — a Chinese state-controlled media outlet with 88 million followers — Facebook posts citing the Placer County Sheriff’s Office statement as its source garnered thousands of comments, shares and reactions on the website.

The Sheriff’s Office took a combative tone in some of its comments responding to Facebook users beneath its own post. To the woman who wrote that its statement was “vague and terrifying,” sheriff’s officials penned a reply that began: “Too bad.”

“We also have protocols and policies to follow, and we are releasing what we can to the public,” that comment continued. “Accuracy trumps instant gratification here.”

In another comment to a different user criticizing the post, the Sheriff’s Office wrote: “If you’re unhappy with the set of information we have provided, feel free to unfollow this page,” a remarkable message coming from a government public safety agency. Sheriff’s offices, including Placer, routinely use their Facebook pages to give followers timely updates on law enforcement activity, wildfire evacuations and other urgent safety threats.
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Re: Coronavirus Crisis: Main Thread

Postby stickdog99 » Tue Jan 26, 2021 5:42 pm

https://sacramento.cbslocal.com/2021/01 ... d-vaccine/

The Placer County Sheriff’s Office announced Saturday that a person tested positive for the virus in late December and died hours after getting the vaccine on Thursday.

Now, there are questions from the community on the safety of the vaccine. An Auburn woman says she witnessed the tragedy first hand.

In a post on Facebook, she said she saw her grandfather’s aid, a 56-year-old man, get the vaccine at a senior living facility on Thursday.

“Twenty minutes later he realized his legs felt tingly and he was having shortness of breath. He was wheeled out in an ambulance…1 hour later he was in ICU on a ventilator and three hours later he passed away,” she wrote.

She goes on to say “Hearing this broke my families [sic] heart as he has taken care of my grandpa for years, and was there helping as we were coming to say our goodbyes.”
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