the case in Washington State
the case in Washington State
Remember that in 1989, after tanks rolled into Tiananmen Square on June 4, some companies were unable to claim force majeure. That’s because Chinese government bodies refused to certify that something abnormal had happened in Beijing. This time, several questions need to be answered before assessing the feasibility of force majeure claims.
First, many of the restrictive measures, such as quarantine or denying access, were actually imposed by local police, city governments and provincial governments. Although many decisions were reported to and cleared by the Chinese central government, the opacity of the decision-making process may well impede Chinese companies from using force majeure claims to cancel contracts with foreign entities. Beijing would do well to streamline and increase the transparency of its decision-making process so that local companies can prove the existence of a force majeure situation.
Second, some Chinese local and central government officials have given very reassuring statements on the limited impact of the outbreak. These are intended to bolster domestic confidence in face of this terrible epidemic. The Chinese Ministry of Foreign Affairs even criticised the US and some other western governments for the wave of travel restrictions. These statements could be used to argue that the impact of the outbreak has been somewhat limited, and are therefore not a justification for cancelling contracts. The WHO’s decision not to impose travel restrictions is also problematic.
A Solano County resident appears to be the nation’s first case of coronavirus infection from an unknown source, fueling concern that the virus could spread undetected in the general population.
Unlike other cases, the person did not recently return from a foreign country or have contact with a person who was known to be sick or infected, according to the U.S. Centers for Disease Control.
https://www.thereporter.com/2020/02/26/ ... -tells-us/
Belligerent Savant » Sat Feb 01, 2020 12:14 am wrote:.Since the S protein of 2019-nCoV shares closest ancestry with SARS GZ02, the sequence coding for spike proteins of these two viruses were compared using MultiAlin software. We found four new insertions in the protein of 2019-nCoV- “GTNGTKR” (IS1), “HKNNKS” (IS2), “GDSSSG” (IS3) and “QTNSPRRA” (IS4) (Figure 2). To our surprise, these sequence insertions were not only absent in S protein of SARS but were also not observed in any other member of the Coronaviridae family (Supplementary figure). This is startling as it is quite unlikely for a virus to have acquired such unique insertions naturally in a short duration of time.
The insertions were observed to be present in all the genomic sequences of 2019-nCoV virus available from the recent clinical isolates. To know the source of these insertions in 2019-nCoV a local alignment was done with BLASTp using these insertions as query with all virus genome. Unexpectedly, all the insertions got aligned with Human immunodeficiency Virus-1 (HIV-1). Further analysis revealed that aligned sequences of HIV-1 with 2019-nCoV were derived from surface glycoprotein gp120 (amino acid sequence positions: 404-409, 462-467, 136-150) and from Gag protein (366-384 amino acid) (Table 1). Gag protein of HIV is involved in host membrane binding, packaging of the virus and for the formation of virus-like particles. Gp120 plays crucial role in recognizing the host cell by binding to the primary receptor CD4.This binding induces structural rearrangements in GP120, creating a high affinity binding site for a chemokine co-receptor like CXCR4 and/or CCR5.
https://www.biorxiv.org/content/10.1101 ... 0.927871v1
14% of recovered coronavirus patients in China's Guangdong tested positive again
Published Feb 26, 2020, 10:06 am SGT
By Li Liuqian, Huang Shulun and Han Wei
(CAIXIN GLOBAL) - About 14 per cent of patients who recovered from the novel coronavirus and were discharged from hospitals in southern China's Guangdong province were tested positive again in later check-ups, according to the local health authority.
A positive test suggests the recovered patients may still carry the virus, adding complexity to efforts to control the outbreak.
There is no clear conclusion on why it happens and whether such patients could still be infectious, said Song Tie, deputy director of the Guangdong Centre of Disease Control And Prevention (Guangdong CDC), at a Tuesday (Feb 25) briefing.
According to the preliminary assessment, experts believed the patients are still recovering from lung infections and have yet to be fully healthy, according to Song.
According to the latest treatment guidelines for the Covid-19 issued by the National Health Commission, patients can be considered recovered and released from hospital when their throat or nose swabs show up negative in two consecutive tests, with a CT scan indicating no lung lesions, and when they have no obvious symptoms such as fever.
The guidelines suggest recovered patients should monitor their health and limit outdoor activities for two weeks after leaving the hospital, and check in for retesting in following weeks.
Some patients' test results returned to positive in the follow-up checks, said Li Yueping, director of the intensive care unit at Guangzhou No.8 People's Hospital at the briefing.
The No.8 People's Hospital has found 13 discharged patients that tested positive again, although none showed renewed symptoms, according to Li. Nucleic acid tests for 104 close contacts of the patients all found negative results, said Li.
Cai Weiping, director of the Infectious Diseases Division of the No.8 People's Hospital, told Caixin that the positive results in the recovered patients were all found from anal swabs, a method rarely used in other parts of the country. Their results were in the "weak positive" range, said Cai.
The national treatment guideline only requires tests from throat or nose swabs for suspected patients as the virus is believed to spread mainly via respiratory droplets produced when an infected person coughs or sneezes.
But research by Guangzhou Medical University found the virus in fecal samples, suggesting a new path of transmission. Some hospitals in Guangdong have since adopted the anal swab in virus tests.
Cai said it is still unclear whether the virus detected in the recovered patients is still active. There is also the possibility of a discrepancy in samples, he said.
Song at Guangdong CDC said the province is preparing to put those recovered patients who re-tested positive under concentrated observation. Health authorities will also step up monitoring of discharged patients and their condition as they recover, said Song.
By the end of Monday, Guangdong reported 1,347 infections and 805 recoveries. The death toll reached seven, official data showed.
Similar cases of recovered patients testing positive have been reported elsewhere in China.
Last week, a patient initially discharged after recovering in southwestern Sichuan province's Chengdu city was readmitted after testing positive again in later check-ups.
Health authorities in the southern island province of Hainan also confirmed that some recovered patients had tested positive again. The authorities required discharged patients to stay home under quarantine for 14 days, and allowed them to be released after both throat and anal swab tests showed negative.
Japan confirms first case of person reinfected with coronavirus
The reinfection has health officials worried the illness could stay dormant after signs of recovery.
By Joseph Guzman
Japan is reporting its first case of a person becoming reinfected with the coronavirus after showing signs they had fully recovered, according to Reuters.
Osaka’s prefectural government confirmed Wednesday a woman working as a tour bus guide tested positive for coronavirus for the second time after developing a sore throat and chest pain. The woman, who is said to be in her 40s, first tested positive in late January and was discharged from the hospital on Feb. 1 after showing signs of recovery.
Reuters reports Health Minister Katsunobu Kato said the government would need to monitor the condition of others who were infected and later discharged as health experts investigate testing positive for COVID-19 after an initial recovery.
As much remains unknown about the virus, cases of reinfection have health experts worried that the illness could remain dormant after an apparent recovery.
“Once you have the infection, it could remain dormant with minimal symptoms,” Philip Tierno Jr., professor of microbiology and pathology at New York University, told Reuters.
“And then you can get an exacerbation if it finds its way into the lungs,” he said.
There have been a number of cases of reinfection in China, particularly in Wuhan province where the coronavirus outbreak originated in late December.
There are more than 200 confirmed cases of the flu-like illness in Japan, excluding the 639 cases from the Diamond Princess cruise ship under quarantine in Yokohama.
The country’s schools are being asked to close from March 2 until their upcoming spring break in an effort to contain the virus, Prime Minister Shinzo Abe said Thursday.
The outbreak has spread rapidly, infecting about 80,000 people worldwide and leaving nearly 2,800 dead, the majority of which have been in mainland China.
Published on Feb 27, 2020
Grizzly » Thu Feb 27, 2020 6:08 pm wrote:
So, I take it, they went ahead with 'terror stock trading' , like they named it during Bush the lessor years, which got folks upset, so they dropped the idea, to only go ahead with it. Nice world we got, here...
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