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Huh, this is weird. That's the exact same thing I've been saying all along. I also heard cats and dogs are now living together.
I think we're looking at the same thing from (very) different vantage points.
I'm not sure recognition of the problem will open any new and novel worlds of possibilities though. It will just be one more data point in a sea of competing data points. It might lead to new insights and progress in various aspects of human existence, but ultimately we're still human, and that usually ends with dead people and children crying.
We're already straining at the limits of what our nature will allow.
We're seeing the backlash right now with the rise of the new right wing and their yearning for "traditional" values which is threatening to drag us all back down to the good old days where things weren't so confusing and scary.
An Ancient Virus May Be Responsible for Human Consciousness
https://www.livescience.com/61627-ancient-virus-brain.html
By Rafi Letzter, Staff Writer | February 2, 2018 12:18pm ET
You've got an ancient virus in your brain. In fact, you've got an ancient virus at the very root of your conscious thought.
According to two papers published in the journal Cell in January, long ago, a virus bound its genetic code to the genome of four-limbed animals. That snippet of code is still very much alive in humans' brains today, where it does the very viral task of packaging up genetic information and sending it from nerve cells to their neighbors in little capsules that look a whole lot like viruses themselves. And these little packages of information might be critical elements of how nerves communicate and reorganize over time — tasks thought to be necessary for higher-order thinking, the researchers said.
Though it may sound surprising that bits of human genetic code come from viruses, it's actually more common than you might think: A review published in Cell in 2016 found that between 40 and 80 percent of the human genome arrived from some archaic viral invasion. [Unraveling the Human Genome: 6 Molecular Milestones]
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That's because viruses aren't just critters that try to make a home in a body, the way bacteria do. Instead, as Live Science has previously reported, a virus is a genetic parasite. It injects its genetic code into its host's cells and hijacks them, turning them to its own purposes — typically, that means as factories for making more viruses. This process is usually either useless or harmful to the host, but every once in a while, the injected viral genes are benign or even useful enough to hang around. The 2016 review found that viral genes seem to play important roles in the immune system, as well as in the early days of embryo development.
But the new papers take things a step further. Not only is an ancient virus still very much active in the cells of human and animal brains, but it seems to be so important to how they function that processes of thought as we know them likely never would have arisen without it, the researchers said.
The Arc gene
Shortly after a synapse fires, the viral gene known as Arc comes to life, writing its instructions down as bits of mobile genetic code known as RNA, the researchers found. (A synapse is the junction between two neurons.)
RNA is DNA's messenger and agent in the world outside the cell's nucleus. A single-strand copy of code from DNA's double helix, it carries genetic instructions to places they can be useful. (And, interestingly, viruses tend to store their genetic code in RNA, rather than in DNA.)
Following the Arc RNA's instructions, the nerve cell builds "capsids" — virus-like envelopes — around it. Those envelopes let it travel safely between cells, and it does just that, entering neighboring neurons and passing its packet of genetic information along to them, according to the studies.
It's still unclear what that information does when it arrives in a new cell, but the researchers found that without the process functioning properly, synapses wither away. And problems with the Arc gene tend to show up in people with autism and other atypical neural conditions, the researchers said.
In a companion article, two experts who were not involved in the 2018 papers (the same two experts, in fact, behind the 2016 review) wrote that this process offers the best explanation yet for how nerve cells exchange the information necessary to reorganize themselves in the brain over time.
"These processes underlie brain functions ranging from classical operant conditioning to human cognition and the concept of 'self,'" they wrote. (Classical and operant conditioning are simple forms of reward and punishment-based learning in animals and humans.)
Bizarrely, Arc seems to have made the jump from virus to animal more than once. The researchers found that Arc genes in humans and other four-limbed creatures seem to be closely related to one another. The Arc genes in fruit flies and worms, however, seem to have arrived separately.
The next step for this research, the outside experts wrote in the companion article, is to bring experts in neuroscience and ancient viruses together to work out the mechanisms for just how Arc arrived in the genome, and exactly what information it's passing between our cells today.
Burnt Hill » Sat Feb 03, 2018 1:29 am wrote:Chris Crawford -
"The headline is misleading. The Arc gene sequence is involved in neuronal behavior in ALL animals. If it lies behind consciousness, then doesn't that mean that all animals with the Arc gene are conscious? Does that mean that fruit flies are conscious?"
"This is a very significant discovery; it might be crucial to learning"....snip...
Arc Weld
“Language is a virus from outer space”
—William S. Borroughs
Chest-thump to start off the year: Last year’s “ZeroS”, appearing in Jonathan Strahan’s Infinity Wars, made it into a couple of (late-breaking update: into three!) Year’s Best collections: Neil Clarke’s Best Science Fiction of the Year (Vol. 3), and another couple I hesitate to name because they don’t seem to have been announced yet. So that’s cool.
But this is way cooler:
There’s this gene, Arc, active in our neurons. It’s essential for cognition and longterm memory in mammals; knockout mice who lack it can’t remember from one day to the next where they left the cheese. It looks and acts an awful lot like something called a gag— a “group-specific antigen”, something which codes for the core structural proteins of retroviruses. Like a gag, Arc codes for a protein that assembles into capsids (basically, shuttles containing messenger RNA). These accumulate in the dendrites, cross the synaptic junction in little vesicles: a payload from one neuron to another.
Pastuzyn et al, of the University of Utah, have just shown that Arc is literally an infection: a tamed, repurposed virus that infected us a few hundred million years ago. Apparently it looks an awful lot like HIV. Pastuzyn et al speculate that Arc “may mediate intercellular signaling to control synaptic function”.
Memory is a virus. Or at least, memory depends on one.
Of course, everyone’s all over this. U of Utah trumpeted the accomplishment with a press release notable for, among other things, describing the most-junior contributor to this 13-author paper as the “senior” author. Newsweek picked up both the torch and the mistake, leading me to wonder if Kastalio Medrano is simply at the sloppy end of the scale or if it’s normal for “Science Writers” in popular magazines to not bother reading the paper they’re reporting on. (I mean, seriously, guys; the author list is right there under the title.) As far as I know I’m the first to quote Burroughs in this context (or to mention that Greg Bear played around a very similar premise in Darwin’s Radio), but when your work gets noticed by The Atlantic you know you’ve arrived.
Me, though, I can’t stop thinking about the fact that something which was once an infection is now such an integral part of our cognitive architecture. I can’t stop wondering what would happen if someone decided to reweaponise it.
The parts are still there, after all. Arc builds its own capsid, loads it up with genetic material, hops from one cell to another. The genes being transported don’t even have to come from Arc:
“If viral RNA is not present, Gag encapsulates host RNA, and any single-stranded nucleic acid longer than 20-30 nt can support capsid assembly … indicating a general propensity to bind abundant RNA.”
The delivery platform’s intact; indeed, the delivery platform is just as essential to its good role as it once was to its evil one. So what happens if you add a payload to that platform that, I dunno, fries intraneuronal machinery somehow?
I’ll tell you. You get a disease that spreads through the very act of thinking. The more you think, the more memories you lay down, the more the disease ravages you. The only way to slow its spread is to think as little as possible; the only way to save your intelligence is not to use it. Your only chance is to become willfully stupid.
Call it Ignorance is Bliss. Call it Donald’s Syndrome. Even call it a metaphor of some kind.
Me, I’m calling it a promising premise. The only real question is whether I’ll squander it now on a short story, or save it up for a few years and stick it into Omniscience.
(Thanks to Bahumat, btw, for showing me the link.)
DrEvil » Sat Feb 03, 2018 3:29 pm wrote:Peter Watts has some of his usual cheerful speculation on this. Short version: the virus still contains all it needs to act like a virus, so how long until someone creates a new payload for it and weaponizes it? A virus that literally spreads by the power of thought.
dada » Sat Feb 03, 2018 11:52 pm wrote:DrEvil » Sat Feb 03, 2018 3:29 pm wrote:Peter Watts has some of his usual cheerful speculation on this. Short version: the virus still contains all it needs to act like a virus, so how long until someone creates a new payload for it and weaponizes it? A virus that literally spreads by the power of thought.
By his science fiction logic, wouldn't it be possible to create a payload to some positive end? Does weaponizing always have to be to some destructive end? Maybe this destructive tendency of thought has something to do with training your mind to think of catchy ideas that will sell stories. Which would imply that not only are memory, language, and even thought itself viruses, but consumerism behaves similarly. Catchy ideas. Perhaps it would be illuminating to look at many human processes and behaviors through the virus framework.
It's difficult to imagine constructive weapons, isn't it. Destructive comes easy for us. The infection must be very advanced.
Although, difficult means a challenge. And I find challenges attractive. Perhaps there's hope in that.
Somehow this brings to mind Terry Riley's repurposing of factories so the smokestacks belch incense instead of smog.
Burnt Hill wrote:Weaponized memory viruses, I already have a few that I created myself, I think
DrEvil wrote:You could probably come up with positive payloads to spread, like increased altruism or reducing the impact of negative memories, but then it would probably backfire spectacularly, people becoming altruistic to the point of starving to death because they don't want to eat living things or can't stand the thought of children starving in Africa while they themselves eat, or the reduced impact of negative memories makes people incapable of learning from their mistakes.
I think people's tendency to think negatively is a survival trait. Imagining a happy outcome is nice but won't do much else, while imagining a bad outcome might help you prevent the bad outcome from happening.
To paraphrase Watts: The guy who assumes the rustling in the grass is a tiger will run away and have children. The guy who assumes it's just the wind won't.
Burnt Hill » Sat Feb 03, 2018 10:54 pm wrote:Thanks for that DrEvil.
Weaponized memory viruses, I already have a few that I created myself, I think.....
dada » Sun Feb 04, 2018 3:11 am wrote:Burnt Hill wrote:Weaponized memory viruses, I already have a few that I created myself, I think
Homebrew memory viruses. Now we're sliding from scientific into alchemical territory. ha
Treating memory like a mechanical system might provide some answers to some questions, but it may fail to address others. Different contexts, even different scientific ones, reveal different aspects.
Besides that, memory is a word that covers a complex of subjects. An actor memorizing Shakespeare, or Kyrgyz Manaschi reciting a five hundred thousand line epic poem may be using a different type of memory than remembering what I ate for dinner on Wednesday.
There's the stroll down memory lane, there's Proust's involuntary memory, there's unconscious memory. All are subjective, selective; we assign significance to a small fraction of what we actually perceive with our senses. And even that we can get wrong. It may not be a matter of failure of memory, it could be distraction, where we place the focus of attention. What we assign as significant memories is bound up with our sense of identity, personality, ego, along with whatever we currently have swimming around in our subconscious. All of which can change. Nostalgia narrows our view. There may be ways to widen it. Just some thoughts.DrEvil wrote:You could probably come up with positive payloads to spread, like increased altruism or reducing the impact of negative memories, but then it would probably backfire spectacularly, people becoming altruistic to the point of starving to death because they don't want to eat living things or can't stand the thought of children starving in Africa while they themselves eat, or the reduced impact of negative memories makes people incapable of learning from their mistakes.
I think people's tendency to think negatively is a survival trait. Imagining a happy outcome is nice but won't do much else, while imagining a bad outcome might help you prevent the bad outcome from happening.
To paraphrase Watts: The guy who assumes the rustling in the grass is a tiger will run away and have children. The guy who assumes it's just the wind won't.
All true. But I'm thinking positive payloads like ways to speed up the healing process. Heal a cut, increase white blood cell count, knit bones faster just by thinking about it. Clearly the mind influences the body, maybe we could enhance that. When we think we see a tiger, adrenalin courses through the body. When we realize it's a shadow, we relax. Perception drives the chemicals.
I'm tough on science fiction writers, extra-critical. I think they have a great responsibility.
DrEvil » Mon Feb 05, 2018 8:17 pm wrote: ..the problem of unintended consequences. How do you prevent people from getting cancer every time they're angry or depressed, and how do you prevent hypochondriacs from dropping like flies?
I agree completely on science fiction writers, but for me that also includes authors like Watts to show us the dark side of our potential futures.
So many of the people creating our future look to optimistic science fiction for inspiration, like Musk naming his drone ships after Culture ships, Google having the Star Trek computer as the design goal for their search/voice assistant and everyone into augmented reality poring over Rainbow's End that someone needs to play devil's advocate and say "hang on, this is going to end horribly, and here's why".
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