Coronavirus Crisis: Main Thread

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Re: Coronavirus Crisis: Main Thread

Postby Harvey » Tue Feb 01, 2022 9:24 pm

The pandemic now setting in might trigger one of those fears that cause structural changes. Then we will be able to lay the foundation for a world government, something to accomplish much faster than would have been possible by economic reasons alone.


Jacques Attali in 2009
And while we spoke of many things, fools and kings
This he said to me
"The greatest thing
You'll ever learn
Is just to love
And be loved
In return"


Eden Ahbez
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Re: Coronavirus Crisis: Main Thread

Postby PufPuf93 » Tue Feb 01, 2022 9:32 pm

Harvey » Tue Feb 01, 2022 6:24 pm wrote:
The pandemic now setting in might trigger one of those fears that cause structural changes. Then we will be able to lay the foundation for a world government, something to accomplish much faster than would have been possible by economic reasons alone.


Jacques Attali in 2009


Harvey

This is basically what I have concluded. A pandemic is being used to foster a number of agendas. I expect a Mad Max Hell with secure islands of the rich and powerful rather than a successful one world government will be the result.
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Re: Coronavirus Crisis: Main Thread

Postby Belligerent Savant » Tue Feb 01, 2022 10:15 pm

PufPuf93 » Tue Feb 01, 2022 7:41 pm wrote:
Harvey » Tue Feb 01, 2022 4:39 pm wrote:
PufPuf93 » Wed Feb 02, 2022 12:23 am wrote:
Belligerent Savant » Tue Feb 01, 2022 3:25 pm wrote:.

What is your point in sharing the above, other than to expose your willingness to be duped by partisan tropes? Falling for base-level misdirections.

Why was the 15% unvaccinated bit highlighted?


The truckers in the Ottawa demonstration do not represent the majority of Candian truckers, a significant number of the demonstrators are not even truckers so it is said.

I am not going to link it but there is a long twitter thread linking / seeding the organization of the Canadian trucker protest to Russian twitter accounts by 1000s of posts from allegedly known operatives, some of which if one looks at other of their twitter topics are unashamed contemporary Russian Nazis and have many posts in an alphabet and language I cannot read.

You are an individual that catapults crappy propaganda and think your volume gives you the privilege to lord and insult over others. You are the one that is caught up in an ugly mind fuck.

There are parties that want to generate chaos for their own maybe even conflicting ends. They are doing everything possible to destabilize the World and the USA too. Why? Humanity has always been cursed by those that gain from chaos and hurting others.

The 15% is stated by the Canadian Truckers Association of their members that are not vaccinated.


Should be easy to prove.


Here is link to the 15% and about the Canadian Truckers Alliance already posted on the last page.

https://abcnews.go.com/International/wi ... t-82497084

I am not going to post the Russian Twitter accounts.

IMO what I bolded from my previous post about induced chaos is where RI should be focused by that ship has sailed long ago. alas.


Puf - you presume too much about my position on this. I've said many times here, broadly, that there is always the potential for limited hangouts and poisoned wells. I understand you may have no interest in reading my content in more detail, but then please endeavor to avoid broad brush mischaracterizations of my thinking process.

With respect to this:

There are parties that want to generate chaos for their own maybe even conflicting ends. They are doing everything possible to destabilize the World and the USA too. Why? Humanity has always been cursed by those that gain from chaos and hurting others.


This certainly appears to be the case. Dwindling resources, supply chain issues, inflation, low food inventory, divisive rhetoric to stoke hatred among classes and races, etc.

Perhaps the top-tier of the .01% years ago came to the conclusion -- however soundly, or not -- that available resources are limited and a culling was in order. 2020 may have been the onset of a more aggressive push towards these ends.

The prospects for clarity on these questions remain dim. But those of us with a measure of heightened awareness can prepare and adjust accordingly.
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Re: Coronavirus Crisis: Main Thread

Postby Belligerent Savant » Tue Feb 01, 2022 10:38 pm

MacCruiskeen » Tue Feb 01, 2022 5:37 pm wrote:Trudeau is a ridiculous and sinister phoney, but that alleged tweet is also an obvious fake. For a start (and quite apart from the style and substance), Twitler has a character-limit.


Yes. I should have added a proper disclaimer, or excluded it outright.

That said, this tweet here is genuine. Divisive rhetoric among leadership. Who aligns with this?

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Re: Coronavirus Crisis: Main Thread

Postby PufPuf93 » Tue Feb 01, 2022 11:48 pm

BS

Bet you would be surprised just how much I do read. I essentially at least scan every post at RI. I seldom watch videos because they are so time demanding and my satellite internet connection almost never does HD so live with SD that comes and goes like the weather. I don't pay anywhere as much attention to charts as early in covid time.

What you post varies in quality. Some of the more questionable items have been posted in comment sections of two highly contentious local news blogs I regularly read. Figure they came from a common source.

What Harvey posted about induced human population decline is my perception.

Maybe what is going on medically with covid is fate; the attempt to isolate and trace infection was doomed to fail. Think the forest fire analogy works here; first try to stop the various spot fires, then back off to what are hopefully good control lines. That did not work. Recall the masks were more to slow the spread than to keep folks from getting infected. Now talk is of herd immunity and an endemic virus; but no one knows what herd immunity or endemic will look like. But we talk here at RI about circuit boards injected in the blood stream and the idea that viruses don't exist and that covid is a fraud. What we should be worrying about is more mutations which are essentially a sure thing. The reality is that our social stability and common causes are being torn to shreds by the externalities.

In the USA we dealt with measles and polio and the like as public health issues; covid has been politicized and weaponized to set everyone against each other and we do not know up from down. This is the manipulation. Those we should fear figure they will survive and have more stuff.

The crisis we face as human is basic population ecology; we have too big a footprint on the planet. Population is fated to decline but as societies we have some choice in how population declines. Covid may be a disease that prunes humanity of the old, ill, and less suited genetically in the near term. But I do think covid is manipulated in a manner that could not occur prior to the internet and social media. Brave new world.
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Re: Coronavirus Crisis: Main Thread

Postby Belligerent Savant » Wed Feb 02, 2022 12:33 am

.
Probably one of the most accurate and succinct takes on covid:

If only we could have seen the pandemic as something to be endured, survived, mitigated – rather than controlled or ended through our interventions – then we could have been in a much better place.

- Mark, in the comments section, here:
http://www.luterra.com/blog/?p=1390
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Re: Coronavirus Crisis: Main Thread

Postby drstrangelove » Wed Feb 02, 2022 4:06 am

PufPuf93 » Tue Feb 01, 2022 11:48 pm wrote:The crisis we face as human is basic population ecology; we have too big a footprint on the planet. Population is fated to decline but as societies we have some choice in how population declines.


And this is the thing that gets me with the vaccines. Not the VAERS data or any other evidence for that matter.

Why would these people so very aware of this issue mandate the use of a vaccine that is a net benefit to population growth in the long run? Why not just develop a vaccine which doesn't work instead? Which appears to be closer to the truth. But if the vaccine just doesn't work, then why are they forcing everyone to take it at the cost of political stability?

With the amount of synthetic products we have later discovered cause cancer, it would be unsurprising if mRNA vaccines rapidly increase the speed at which cancer grows within the body. If you were going to do population culling with a vaccine, you wouldn't do it in such a way that everyone was dropping dead. You'd use a slow poison the effects of which gradually build over a number of years.

You have the virus circulating, culling the weak and fragile, who are marked as such by their weakened immune systems. But is this enough of a population reduction? If not, then you need a more dangerous virus, which isn't safe because you can't control it. But you can control the administration of the cure. Specifically in batches.

Could this be done? Yes.

Would the people running things actually do this? Yes.

Have they? :shrug:
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Re: Coronavirus Crisis: Main Thread

Postby stickdog99 » Wed Feb 02, 2022 5:33 am

PufPuf93 » 02 Feb 2022 00:52 wrote:
stickdog99 » Tue Feb 01, 2022 4:54 pm wrote:How is it that pointing the finger at Russia or calling the trucker convoy a totally fringe movement is somehow supposed to allow one to continue supporting vaccine mandates for an omicron variant that we all know and agree said vaccines don't protect against?

Can anyone explain that to me?


Think maybe you should ask some of the medical students that you teach. :tongout


I think you should ask yourself.

Were I to ask my students this obvious question, some of them would undoubtedly report me to the administration, and I would then be summarily fired from my job. To a hearty round of applause from you for daring to ask?
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Re: Coronavirus Crisis: Main Thread

Postby MacCruiskeen » Wed Feb 02, 2022 8:24 pm

Harvey » Tue Feb 01, 2022 5:41 pm wrote:
Harvey » Mon Jan 31, 2022 11:13 pm wrote:--------------------------------------------------------------------------------------------------------------------------------> https://archive.md/O8uUS


I notice this site is already gone. Did anyone else happen to snag the pictures before it went?


Luckily, someone had the foresight to mirror it. Here: https://archive.md/O8uUS#selection-494.0-541.22

Nanotech in the shots?
By Editor
January 29, 2022
For those who just want the short story:
Here’s the picture of one drop of New Zealand’s Pfizer COMIRNATY “vaccine” under a cover slip, after it was inadvertently heated lightly, and viewed the same day through dark field microscopy at low magnification, projected onto a TV monitor.
Image
[...]
https://archive.md/O8uUS#selection-494.0-541.22
"Ich kann gar nicht so viel fressen, wie ich kotzen möchte." - Max Liebermann,, Berlin, 1933

"Science is the belief in the ignorance of experts." - Richard Feynman, NYC, 1966

TESTDEMIC ➝ "CASE"DEMIC
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Re: Coronavirus Crisis: Main Thread

Postby stickdog99 » Wed Feb 02, 2022 9:20 pm

https://nakedemperor.substack.com/p/why ... anging-and

Image

Whilst the narrative change is welcome, it all seems to be happening at the same time, in multiple countries and all whilst Covid cases are hitting new highs. Now I know, cases don’t mean anything unless they convert to hospitalisations and deaths but still, even a few weeks ago, if cases were rising, the media and politicians would be going into fear overload.

Let’s take a look at a few example countries and how the same narrative change has been happening over and over again. I will look at the countries in order of most vaccinated,

Gibraltar

Image

With cases at all time highs on 25th January the Gibraltar Government said it will “continue to be guided by scientific advice” after the GSD said Gibraltar “must now learn to live with Covid”. The GSD said a successful vaccination programme was “clearly being effective at staving off hospitalisations despite a high level of community infection”.

Denmark

Image

Denmark is becoming the first EU country to scrap all COVID-19 restrictions, on 1 February, just as cases are at an all time high. The Danish health minister said “we have this decoupling between infections and intensive care patients, and it is mainly due to the large attachment among Danes to revaccination.”

Hospital admissions and deaths would suggest otherwise.

Image

Image

Iceland

Image

Iceland are to relax restrictions despite record numbers of infections. The reason for the change in tactics is the change in the pandemic’s behaviour. With the introduction of the omicron variant, as well as 78% of the nation being fully vaccinated and over 50% having had their booster shot, the National Hospital’s data indicates that the risk of serious illness is much less than it was.

Again, hospitalisations don’t reflect this.

Image

Italy

Image

From 1 February, Italy will ease COVID-19 restriction for all travellers from EU countries. At the moment, all citizens must present a negative test on arrival, however, since the Omicron variant is already widely spread within the EU, the authorities plan to remove the pre-entry testing requirements if they present a valid vaccination or recovery certificate.

Portugal

Image

Portugal, despite huge case numbers, will change the rules so that passengers will face milder entry rules, provided they have completed their immunisation process against the virus. This must be evidenced by a valid EU digital COVID certificate. In addition, from 1 February the EU will shorten the validity of vaccination documents to 270 days.

Belgium

Image

Rising cases has not prevented Belgian authorities from removing travel bans. Furthermore, they have revealed new rules with regard to vaccination certificates. From 1 March, the validity passes will be reduce from 270 to 150 days. Such a decision was taken in order to push more people to get an additional dose and means that all those who hold a vaccination certificate indicating that the last dose was taken more than 150 days will be considered unvaccinated. On the other hand, those who receive a booster shot will be able to travel under facilitated rules.

The list goes on and on. France are lifting most of its Covid restrictions, although vaccine passes will come into effect on Monday. People will no longer be allowed to show a negative test to enter restaurants, bars, theatres or travel on trains.

In the UK, most Covid restrictions have been removed, including mandatory COVID-19 certification, but venues can choose to use the vaccine pass voluntarily. Our health secretary, Sajid Javid, says the plan to live with Covid will focus on vaccines, treatment drugs and testing. He said a plan on how we will “learn to live with Covid as a country” will be published by spring.

It seems the new narrative is “living with the virus”. What this means in reality is that mass vaccination has caused massive spikes in cases. This is due to the negative efficacy towards infections. Moreover, whilst hospitalisations and deaths are relatively low, they will take advantage of the situation and claim victory due to the vaccines. The real reason will be that Omicron is more mild and that the majority of susceptible individuals will have already been hospitalised or died from a previous variant.

This hollow, Pyrrhic vaccine victory will be used to further the use of vaccine passports. Negative tests will be removed and places and services that require Covid passes will only be accessible to the vaccinated. Exemptions will be extremely difficult to acquire and any attempts to bypass the system will result in hefty fines or jail time. In the UK, we already have £10,000 fines for attempting to forge a Covid pass.

It is clear that the only way to keep your vaccine passport is by having a booster. Moreover, following Belgium’s example, an updated booster will be required within 150 days (5 months).

I remain naively and optimistically positive that this won’t happen in a free country such as the UK but all the signs are that this is already in motion. I have little hope for the EU and even less for Canada, Australia and New Zealand. The US has strong resistance but ultimately they will fall in line as well. I can’t see any international travel happening without the passes this year.

So the narrative change is happening in lockstep because it must be done so. For the majority to accept vaccine passports, it must be easy and with little difference between countries. By spring, due to seasonality, cases will be subsiding and this will be used to further the use of vaccine passports. Vaccines have saved us, they reduced hospitalisations and deaths and now they are reducing cases.

Whilst we have been rejoicing that restrictions are loosening, the vaccine passport plan has been progressing behind our backs. Classic diversionary tactics. Once the majority are boosted, rules are homogenised and cases dropping, they will double down on the vaccine passports. Why will the majority go along with this? Because they are too busy with everyday life to care, so long as it doesn’t affect them. You can already see this with masks. Worn in empty locations because they are told to. Not worn in crowded locations because they are told to. Put on in a restaurant to walk to a table, but not whilst seated, because they are told to. And when you ask them why, they just shrug and say, “those are the rules”.


I hope I am wrong, but after looking at what each country is doing and preparing to do, all along similar time frames and whilst case rates are high, it seems the writing is on the wall.
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Re: Coronavirus Crisis: Main Thread

Postby stickdog99 » Wed Feb 02, 2022 9:24 pm

https://markchangizi.substack.com/p/if- ... youre-ugly

If a kid says you're ugly, you're ugly.

Same for being in a mass delusion

Trouble with mass delusions is that those within it have no idea they’re in it. You can’t argue them out of it.

They’ve come to believe their narrative in the way that everyone comes to believe narratives: via the network of people around them, especially the higher reputation ones. They’re not crazy. And they’re not lying either.

It’s just that the functional network dynamics are broken, and what would usually have been a variety of independent arguments from various sources all got on the same page due to fear and panic.

You and I would have fallen into it if we sat where they sat within the network. Never think otherwise.

(And falling within a mass delusion is no excuse either.)

So, what can we do?

It occurs to me that it has never, in any of our lifetimes, been the case that one side of a debate is accusing the other side of having fallen into a mass delusion, something I mention in this thread.

Nor has it happened that one side unambiguously sees the ever present signs of global mass delusion, something they have never witnessed, nor ever claimed about their opposition.


If we lived in a world where everyone was constantly accusing their opposition of being in a mass delusion, then hearing that accusation would be uninformative.

But we don’t live in such a world.

Other than the folks who grew up with Communism or Islamism, none of us have ever personally experienced anything close to what we experienced starting in March of 2020. Family, friends, colleagues, politicians and everyone had all gone mad. It’s been Alice in Wonderland 24/7 for two years.

Most of us didn’t know what to even call what we were witnessing. Hypnosis? Madness? A coordinated attack from X? And so on.


I’ve been on the front lines communicating to you what mass hysteria is, and researching how it works, but even I probably never once mentioned “mass hysteria” — in writing or speaking — before March of 2020.

The folks brazenly yelling “Mass hysteria!” for two years have zero history of using that phrase. We’re only just learning about it, in an attempt to understand what the hell happened to everyone.

So, in a world like this, if one side of a debate tells you, “You’re in a mass hysteria,” well, that turns out to be informative.

Could we somehow leverage this observation to red pill those within the hysteria?


It’s certainly, all by itself, no magic bullet. All the empirical arguments about the risks of Covid and dangers of the interventions are informative too, and make no impact on the cult members. (And those arguments are at any rate missing the point.)

But… it’s nevertheless another potential angle, one I haven’t actually tried out.

ME: Look, Doug, you’ve known me for forty years. We have disagreed about loads of things. When have I ever accused you, or anyone, of being in a mass delusion?

DOUG: Well. True. You never have.

ME: So, what’s different now that I am for the first time saying this? And so is much of my side, also who have never mentioned ‘mass hysteria’ their whole lives.

DOUG: Maybe you folks are dicks.


Perhaps that’s how the argument can be expected to go.

Or, perhaps there’s some clever angle there that can be leveraged to help us break their Godel-like inability to see what they’ve fallen into.
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Re: Coronavirus Crisis: Main Thread

Postby stickdog99 » Wed Feb 02, 2022 9:34 pm

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Re: Coronavirus Crisis: Main Thread

Postby Belligerent Savant » Wed Feb 02, 2022 10:11 pm

.

For the few here that [inexplicably] continue to subscribe to Fauci's guidance, perhaps the perspective of a theoretical physicist will finally help sway you back into a semblance of reason.



Why I haven't been Goo'ed

Rudolph Rigger
Theoretical physicist with over 30 years research experience. Mostly esoteric quantum mechanics but some cryptography and security experience thrown in for good measure


I’m not averse to putting toxic substances into my body. I enjoy a large brandy and a cigar.

And Skittles.

So why didn’t I choose to get the Goo?

I’ve had lots of vaccines before - left arm, right arm, and both arse cheeks - never thought twice about them. So why my Hesitancy™ over these new covid vaccines?

Initially, I was delighted that something had been developed so quickly. I had hope. Lockdowns, masks, sanitizer and plastic screens had already meant I had to buy a new MoronMeter which could measure beyond a KiloTwat. But governments seemed blind to the data and so I thought, finally, here was something that could get us out of the ridiculous holes we’d dug for ourselves.

If there was a product that could reduce deaths by 90% then, just by vaccinating the elderly and vulnerable, we could reduce the threat level of covid19 to well below that of flu.

Job done.

I didn’t consider myself to be in a very vulnerable category. Not too old, a generous amount of blubber, but not quite in the land whale category and in fairly robust good health. At the end of 2020 I’d already done my own estimation of the risks based on ONS data. Here’s a slightly later version of it (I didn’t save the 2020 version) based on death registration and the assumption of an overall IFR of 0.4%

Image

It’s worth noting that this is very much an overestimation of the risk - and it’s the risk you face if you actually catch covid in the first place - so, conditional upon infection.

What really inspired my Hesitancy™ at the time, though, was the fact that the vaccines had been developed, and mass-produced, so quickly. I was more than happy to let others choose to be the guinea pigs. Personally, I wanted to see how it all played out. Even in my more naïve state back then I was dimly aware that it was very unusual for a new drug, of any kind, to go from invention, trial and then into production in a matter of months.

Even being repeatedly beaten about the head by the Government’s Great Stick of Safety and Effectiveness did not shake my suspicion that the lovely cuddly kitten might grow up to be a Pferal tiger. I wanted to wait and see. I really did want my suspicions to be unfounded. Only some kind of psychopath would be wishing for the vaccines to fail.

Back then, of course, it was all about personal safety - the doctrine of MoralDuty™ had not yet been fully developed as a central plank of the CovidCatechism™.

The initial trial results seemed promising. In the Pfizer trial each group (vaccinated and placebo) numbered about 22,000 people - so 44,000 (approx) in total. In the vaccinated group there were 8 cases of covid19 (defined by symptoms and a positive PCR test). In the placebo arm there were 162 cases of covid19.

Running the numbers, they seemed to show that the efficacy of the vaccine was 95%. But these are relatively small numbers of infections. Even in the placebo group the risk of infection over the trial period can be calculated to be 0.745%. So in the 3 month trial period the risk of (symptomatic) covid infection was below 1%. If you were in the vaccinated group the risk of infection was lower at 0.037%.

Even taking these results at face value and assuming the honesty, integrity and scrupulous morality of Pfizer, we can see that the baseline risk of (symptomatic) covid infection was not all that high (less than 1%).

Hmmm, I thought, I’ll take my chances until I see whether this Goo is actually safe to take.

After seeing the tragic and spectacular failure of these vaccines over the last year, I’m glad I waited. The data has only confirmed, and continues to confirm, the correctness of my initial position. I take no pleasure in that - it is a tragedy of epic proportions that things have gone so wrong and also that so many have been directly harmed by the Ghastly Goo.

According to the Great Narrative of Truth™ the vaccines have saved lives. Maybe they have saved some from a covid death (although I am not entirely persuaded of that - as some professional statisticians have pointed out it’s not that clear a signal of positive efficacy against death when you take all of the confounders and mis-categorization of “vaccinated” into account) - but that’s not really the right way to look at things.

It’s not much use being saved from a covid death if the stuff you take gives you a heart attack. Out of the covid frying pan and into the clot conflagration. So what we really need to assess is whether the vaccine has reduced overall mortality. It doesn’t seem to be the case, so far, with many places seeing worrying rises in excess mortality. Even in the initial trial data there were indications that the vaccines had worsened overall health.

You don’t try and get data hidden for up to 75 years if you don’t have something to hide. The only tenable conclusion is that there’s something desperately wonky with the trial data, data that doesn’t support the Safe and Effective Narrative™. Even if there is some proprietary data with commercial sensitivity to be redacted, you don’t need 75 years to do this.

I’ve written over 50 scientific papers, a load of conference papers, lots of lengthy commercial reports and analyses, more presentations than I care to remember - and that represents only a fraction of the time I’ve spent. So much more time was spent reading, figuring stuff out, attending meetings, and writing reams of pointless bureaucracy too (getting ISO9001 certification, for example, reduced everyone’s output by about 20% I would estimate). I reckon I could get through the Pfizer bumpf on my own in about 6 months - at most.

The other thing that has prevented me from doing my Sacred Duty is the pressure to get vaccinated that has been applied. It has been off the scale. The propaganda and messaging has been bad enough, and also off the scale, but the punitive mandates and so-called passport schemes have been grotesque and deeply unscientific. They make not one jot of medical sense, given the data.

Where there is risk there must always be choice.

This unholy push to enter the Jabbathon has been extraordinary and a huge red flag for me. Like almost everything about this pantodemic it has been insanely out of proportion to the actual threat level.

Image

There’s just something not right about all of this. It’s too much, for too little. Even if we allow for a smidgeon of over-zealous overreaction at the beginning of things - this bloody freakshow has gone on for nearly 2 years. In the UK they have, very grudgingly, rolled back on mandated vaccination for NHS staff - but Mr Malteser Head, Sajid Javid the Health Secretary, was not in the slightest bit gracious about it. He did his best grumpy old git impression as he still castigated the NHS workers for their choice to remain vaccine-free.

Elsewhere in the world the fight is very real and more serious - governments have hurtled down Authoritarian Avenue for no good medical or scientific reason. Let’s hope someone, soon, parks a great big truck in their way - or 50,000 or so.

Image



https://rudolphrigger.substack.com/p/wh ... been-gooed
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Re: Coronavirus Crisis: Main Thread

Postby Belligerent Savant » Wed Feb 02, 2022 10:32 pm

.
Findings that corroborate claims that spike proteins/vaccine mRNA linger markedly longer than initially advertised.

@RajeevJayadevan

Unexpected finding: vaccine mRNA found even at 60 days after vaccination, inside lymph nodes.

Cell paper from Stanford University changes what we know about mRNA vaccines.

They aren’t “self-destructing, transient email messages sent to cells” any more.

https://www.cell.com/action/showPdf?pii ... %2900076-9

Image




Journal Pre-proof

Immune imprinting, breadth of variant recognition and germinal center response in
human SARS-CoV-2 infection and vaccination


Katharina Röltgen, Sandra C.A. Nielsen, Oscar Silva, Sheren F. Younes, Maxim
Zaslavsky, Cristina Costales, Fan Yang, Oliver F. Wirz, Daniel Solis, Ramona A.
Hoh, Aihui Wang, Prabhu S. Arunachalam, Deana Colburg, Shuchun Zhao, Emily
Haraguchi, Alexandra S. Lee, Mihir M. Shah, Monali Manohar, Iris Chang, Fei Gao,
Vamsee Mallajosyula, Chunfeng Li, James Liu, Massa J. Shoura, Sayantani B.
Sindher, Ella Parsons, Naranjargal J. Dashdorj, Naranbaatar D. Dashdorj, Robert
Monroe, Geidy E. Serrano, Thomas G. Beach, R. Sharon Chinthrajah, Gregory W.
Charville, James L. Wilbur, Jacob N. Wohlstadter, Mark M. Davis, Bali Pulendran,
Megan L. Troxell, George B. Sigal, Yasodha Natkunam, Benjamin A. Pinsky, Kari C.
Nadeau, Scott D. Boyd

PII: S0092-8674(22)00076-9
DOI: https://doi.org/10.1016/j.cell.2022.01.018
Reference: CELL 12350

To appear in: Cell

Received Date: 10 November 2021
Revised Date: 3 January 2022
Accepted Date: 20 January 2022

Summary

35 During the SARS-CoV-2 pandemic, novel and traditional vaccine strategies have been deployed
36 globally. We investigated whether antibodies stimulated by mRNA vaccination (BNT162b2),
37 including 3rd dose boosting, differ from those generated by infection or adenoviral (ChAdOx1-S
38 and Gam-COVID-Vac) or inactivated viral (BBIBP-CorV) vaccines. We analyzed human lymph
39 nodes after infection or mRNA vaccination for correlates of serological differences. Antibody
40 breadth against viral variants is less after infection compared to all vaccines evaluated, but
41 improves over several months. Viral variant infection elicits variant-specific antibodies, but prior
42 mRNA vaccination imprints serological responses toward Wuhan-Hu-1 rather than variant
43 antigens. In contrast to disrupted germinal centers (GCs) in lymph nodes during infection,
44 mRNA vaccination stimulates robust GCs containing vaccine mRNA and spike antigen up to 8
45 weeks post-vaccination in some cases. SARS-CoV-2 antibody specificity, breadth and
46 maturation are affected by imprinting from exposure history, and distinct histological and
47 antigenic contexts in infection compared to vaccination.

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Re: Coronavirus Crisis: Main Thread

Postby stickdog99 » Wed Feb 02, 2022 10:51 pm

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