I don't know if this was posted here earlier, sorry if this is a double post but don't want to go through tens of pages...Check the link directly for all the graphs.
This seems really bad. Vaccines shift immune response to immunoglobulin 4, which is normally meant to suppress allergic reactions, not to neutralize viruses. Immunoglobulin3 neutralizes viruses, but after vaccination IgG3 mostly disappears and is replaced by IgG4 which tells the immune system to
tolerate it instead of neutralizing...
https://www.rintrah.nl/the-trainwreck-o ... -response/Do me a favor and pour yourself a drink, you’ll need it by the end of this article.
I’ll try to avoid repeating what we already addressed in the previous two articles on this subject. After mRNA vaccination the immune response against Spike is shifting to IgG4, which is how your body responds after repeat exposure to stuff it needs to tolerate, like bee venom, pollen or peanut proteins.
First the big chart, of what you want to see after a SARS-COV-2 infection:
Left you see who does the neutralization, right you see what percentage of total antibodies they are. Despite being just 3% of your antibody mass, IgG3 is carrying out 42.2% of the neutralization.
IgA is busy in mucus dealing with this virus, IgM responds to the infection by bringing the viral load down, IgG3 then joins the fight and tags any remaining hide-outs this virus has, so that your body doesn’t end up tolerating this nasty sarbecovirus in the background.
If it wasn’t obvious yet, for whatever reason our bodies do seem to be tolerating the spread of this virus through our population. Look at what’s happening to my poor little country:
You just don’t want to see an IgG4 response to a respiratory infection. Out of the IgG’s, it’s mainly IgG3 and some IgG1 you want to see. One of the authors claims that it doesn’t matter that they’re switching to IgG4, because the antibodies don’t just matter for triggering phagocytosis (your immune cells eating the virus particles), they also matter for neutralization.
This is nice and well, but you run into two problems:
The virus evolves. It rapidly evolves to avoid the most neutralizing antibodies. Neutralizing potential against XBB and BQ.1 is basically gone.
IgG4 isn’t really meant for neutralization. Out of the IgG’s, IgG3 is the excellent virus neutralizer. What IgG3 does in the case of SARS2, is that they have their tails bind together. This means that out of all the four subclasses, IgG3 is showing 50-fold stronger neutralization than the other three subclasses against SARS2.
This has never happened before. There are now the known unknowns, like whether the body ends up tolerating persisting infections due to this completely IgG4 dominated response, along with the unknown unknowns, questions we should be asking ourselves that most people haven’t even realized we need to be asking ourselves.
Here’s the big question I run into: So your experiment failed, you created an IgG4 dominant antibody response in soon to be billions of people. The IgG4 antibody response is homogeneous, it’s the same epitopes that everyone is learning now to tolerate.
Are you ready for this one?
What does it mean for other viruses?
That’s the big painful question. If you told me everyone has a different immune response to different regions of Spike, but everyone now deploys IgG4 antibodies to those regions, that would be bad enough for our relationship to SARS-COV-2.
It’s again just this same basic principle I outlined here above, but this time we’re zooming in on this class switch to IgG4. I wouldn’t be worried about the impact on other pathogens if we had some switch to IgG4 that differs from person to person. But everyone now has select amino acid combinations that don’t occur in our own body (that is, peptides that we would normally not tolerate and chase down with antibodies if they show up in our blood), that everyone is now learning to tolerate!
We intervened in something that we just don’t properly understand, at the scale of billions of people.
Allow me to give you an anecdote. Long ago, in the 19th century, a Swedish man named Arrhenius, related to an autistic Swedish girl you might have heard of, realized that we were changing the atmosphere. People thought this was pretty nice, as they assumed it would happen slowly. Eventually most people forgot about it again.
By the 60’s we realized we were now emitting quite a lot of this strange gas, it was changing the atmosphere. Again the experts were not worried. “The ocean will probably deal with it” was the consensus among very smart people, WHOSE SPECIALTY IT WAS TO STUDY THIS SORT OF STUFF. It was only really in the 1980’s, that basically everyone agreed we were dealing with a real problem.
In this context, I want you to have a look at the scientist who announced his findings on Twitter:
If we believed billions were doomed, we would not have celebrated. It’s an interesting finding, but no need to worry.
— Kilian Schober (@kischober) December 24, 2022
I’m an anonymous Dutch college dropout with a predilection for obscure psychedelics, he is a virologist with a Phd. I’d perfectly understand if you wish to believe him over me, that’s the response most people seem to have.
But what I see, is a scientist saying “eh, the ocean will deal with it”.
He is a virologist and things are not going well in the field of viruses. We have too many people dying. We have a sarbecovirus that is not going away. The hospitals around the Western world can’t deal with the burden of sick people anymore.
And most important of all: The children are getting sick.
Maybe you don’t want to endow billions of people with a similar looking IgG4 antibody repertoire targeted at an RNA respiratory virus. Maybe all sorts of respiratory viruses and other pathogens can use that as an opportunity.
You committed an unprecedented experiment with billions of people, our immune systems are now responding in an unprecedented manner to a respiratory pathogen and we now see unprecedented numbers of people sick from respiratory infections.
If you are a virologist, I think you’re supposed to be worried right now.
Update 1: A critique you might have of my warning, that a shift towards IgG4 may impact other respiratory pathogens too, is that cross-reactivity of antibodies may not be sufficient.
And yet, we already know there must be substantial cross-reactivity between SARS2 and a number of other RNA respiratory viruses, for a simple reason: Subunit influenza vaccines (ie not live vaccines) showed a clear 89% reduction in risk of a severe SARS-COV-2 infection.
If influenza antibodies impact SARS2, SARS2 antibodies impact influenza. And if SARS2 antibodies are shifting towards tolerance, that will impact influenza. The impact will merely get more relevant over time, as these other viruses adjust through mutation and natural selection to benefit optimally from this shift towards IgG4.
The original study paper:
https://www.science.org/doi/10.1126/sciimmunol.ade2798Class switch towards non-inflammatory, spike-specific IgG4 antibodies after repeated SARS-CoV-2 mRNA vaccination
Just finished reading it completely, and ....
fuck.This is so, so bad.
